Abstract: OBJECTIVES: To study the effect of induced fatigue of the unaffected limb on the sensory components of standing balance; proprioception and vestibular symptoms in children with hemiplegic cerebral palsy. METHODS: Setting: Outpatient Clinic of Faculty of Physical Therapy, Cairo University. Patients: Twenty-nine children with hemiplegic cerebral palsy [(ages 8.9 ± 2.3 years), motor ability I/II according to the GMFCS and spasticity of I/I+ according to the Modified Ashworth Scale]. Outcome Measures: Before and after the induced fatigue of the unaffected limb, the following measures were recorded: postural balance, using the Biodex Balance System and the Timed Up and Go test; vestibular sense, using the Paediatric Vestibular Symptom Questionnaire; and proprioception measures of both knees, using the Biodex isokinetic dynamometer. RESULTS: There was a significant increase in the post-fatigue values for the overall stability index (p< 0.05), the Timed Up and Go test (p< 0.05), reposition errors of proprioception of the unaffected limb (p< 0.05) and the vestibular questionnaire (p< 0.05); there was a non-significant decrease in the post-fatigue values for reposition errors of proprioception of the affected limb (p= 0.859). CONCLUSION: Fatigue of the unaffected limb negatively affects postural balance and related sensory systems (proprioception of the fatigued limb and vestibular function) but does not have an impact on proprioception of the unfatigued limb.