Affiliations: Department of Pediatrics, GZA St-Augustinus Hospital
Antwerp, Wilrijk, Belgium
Note:  Correspondence: Dr. Karen van Hoeve, Department of pediatrics,
GZA St-Augustinus Hospital Antwerp, Oosterveldlaan 24, 2610 Wilrijk, Belgium.
Tel.: +32 3 4435896; Fax: +32 3 4404374; E-mail:
[email protected], [email protected] gza.be
Abstract: We report a 15-year-old girl with intractable hiccups unresponsive
to high doses of proton pump inhibitors. Further investigations revealed an
acute demyelinating neurological disorder on magnetic resonance imaging of the
brain with a lesion in the brain stem responsible for the hiccups. Hiccups are
a common and usually transient condition. It is rare for it to become
intractable. Persistent hiccups may reflect a serious underlying disease, as in
our case due to a demyelinating disorder. We would like to highlight the
underlying causes of an acute demyelinating neurological disorder and the
characteristics to help with the differential diagnosis.