Affiliations: Division of Critical Care Medicine, Nationwide Children's Hospital, Columbus, OH, USA | The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA
Note:  Corresponding author: Jennifer A. Muszynski, MD, Critical Care Medicine, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205 USA. Tel.: +1 614 722 3438; Fax: +1 614 722 3443; E-mail: [email protected]
Abstract: Primary goals of sepsis therapy include early, appropriate antimicrobial therapy and prompt recognition and reversal of shock. Despite these measures, however, sepsis remains an important source of pediatric morbidity and mortality. Here we review rationale and existing evidence in support of adjunctive sepsis therapies including extracorporeal support, immunomodulation, and mitochondria-targeted therapies. While each of these therapeutic modalities shows promise, additional studies are urgently needed to identify the right patients, the right timing, and the right context for these interventions.
Keywords: Sepsis, extra corporeal membrane oxygenation, renal dialysis, immunomodulation, mitochondria