Affiliations: Division of Pediatric Infectious Diseases, Children's
Hospital of New Jersey, Newark, NJ, USA | Department of Pharmacy, Newark Beth Israel Medical
Center, Newark, NJ, USA | Jersey City Medical Center, Jersey City, NJ, USA | Division of Neonatal Medicine, Children's Hospital of
New Jersey, Newark, NJ, USA
Note: [] Correspondence: Jeremias L. Murillo, Division of Pediatric
Infectious Diseases, Children's Hospital of New Jersey, 201 Lyons Avenue,
Newark, NJ 07112, USA. Tel.: +1 973 322 4015; Fax: +1 973 322 4074; E-mail:
[email protected]
Abstract: An 801 gram very premature infant was delivered by Cesarian section
at 28 weeks gestation and developed invasive Candida parapsilosis infection at
4 weeks of age complicated with obstructive uropathy, bilateral hydronephrosis
and bladder fungus ball. The baby was treated with systemic amphotericin B and
bladder irrigation with amphotericin B solution. Treatment resulted in complete
eradication of the bladder fungus ball and resolution of the obstructive
uropathy. The difficulty of performing bladder irrigation in an extremely small
premature infant is discussed. This case illustrates the need to investigate
for renal involvement in newborns with persistent candidemia and the
effectiveness of bladder irrigation with amphotericin B solution in the
treatment of bladder fungus balls.
