Affiliations: Department of Pediatrics, Marshall University Huntington, WV, USA
Note: [] Correspondence: Maria G. Lopez Marti, Marshall University,
Department of Pediatrics, Div of Pediatric Infectious Disease, 1600 Medical
Center Drive, Suite 3500, Huntington, WV 25701, USA. Tel.: +1 304 691 8679;
Fax: +1 304 691 1345; E-mail: lopezmarti@ marshall.edu
Abstract: We report a case of persistent bacteremia secondary to
methicillin-resistant S. aureus (MRSA) in a preterm neonate successfully
treated with daptomycin. Although the MRSA isolate was susceptible to
vancomycin, there was no clinical or microbiologic response. Within 3 days of
therapy with daptomycin, clinical improvement was noted, along with
sterilization of blood cultures. Little data exist on neonatal pharmacokinetics
of daptomycin. This report highlights the potential advantage that daptomycin
offers in treating severe MRSA infections in neonates.
