Affiliations: Department of Microbiology, Virology Division, Faculty
of Medicine, Chulalongkorn University, Bangkok, Thailand | Department of Pediatrics, Faculty of Medicine,
Chulalongkorn University, Bangkok, Thailand
Note: [] Correspondence: Dr. Parvapan Bhattarakosol, PhD., Department of
Microbiology, Virology Division, Faculty of Medicine, Chulalongkorn University,
Bangkok 10330, Thailand. Tel.: +66 2 256 4132 Ext: 616; GSM: +66 81 824 0258;
Fax: +66 2 252 5952; E-mail: [email protected]
Abstract: The intrauterine transmission rates of cytomegalovirus (CMV) and
herpes simplex virus (HSV) were determined in non human immunodeficiency virus
(HIV)-infected and HIV-infected mothers. Mother-to-child transmission was
defined as polymerase chain reaction positive viruria, and/or viremia. Of 60
mothers, 43 were HIV seropositive. The intrauterine transmission rates of CMV
and HSV as shown in non HIV-infected mothers were 47.06% and 42.86%,
respectively, and in HIV-infected mothers were 40.48% and 66.67%,
respectively. No statistically significant difference was observed between
these two groups (p =0.77 and 0.19, respectively). All intrauterine HSV transmission
occurred in 2 HIV- infected mothers with HSV primary infection while one
non-HIV-infected mother did not transmit. The incidence of symptomatic
congenital CMV infection was found to be 0.04% and none with HSV infection.
This study indicated that co-infection of HIV in pregnant women did not affect
the intrauterine transmission rates of either CMV and HSV.
Screening in utero infection by DNA detection in urin}, white blood cells
and plasma of newborns was recommended.
