Affiliations: Department of Pediatrics, Firat University Faculty of
Medicine, Elazig, Turkiye | Department of Biochemistry, Firat University Faculty
of Veterinary, Elazig, Turkiye
Note:  Correspondence: Dr. Saadet Akarsu, Firat University, Faculty of
Medicine, Department of Pediatrics, 23119 Elazig, Turkiye. Tel.: +90 424
2333555; Fax: +90 424 2388096; E-mail: [email protected]
Abstract: Recent studies have shown that the oxidative state plays an
important role in the pathophysiology of neuroinflammatory diseases.
Determination of erythrocyte arginase, and catalase (CAT), and also plasma and
cerebrospinal fluid (CSF) malondialdehyde (MDA), and nitric oxide (NO)
concentrations were measured to establish differences between antioxidant state
and lipid peroxidationto assess prognosis in neuroinflammatory disease. Three
groups were studied, meningitis (n = 28), encephalitis
(n = 30), and a control group (n = 40) for
the spectrophotometric measurements of arginase, and CAT activities in
erythrocytes, thiosemicarbazide diacetylmonoxime, and Aebi methods were used
respectively. Plasma and CSF MDA levels were analyzed with a modified Yagi
method and NO levels were assessed using spectrophotometric methods using the
Griess reaction. Levels of erythrocyte arginase, erythrocyte CAT, and CSF NO
differed between meningitis and encephalitis (P < 0.05).
While levels of erythrocyte CAT, and CSF MDA, plasma NO and CSF NO
concentrations differed between the meningitis group and controls (P
< 0.05). Concentrations of erythrocyte arginase, CSF MDA and plasma
NO differed between encephalitis and control groups (P <
0.05). All tests in the study except erythrocyte arginase and plasma MDA
differed between meningitis cases and controls (P < 0.05).
In the meningitis and encephalitis cases, studied oxidative states in blood,
and CSF were affected at different levels, meningitis being more severe.