Abstract: Innate component of immunity is a skilful system that senses
invading microbial pathogens and integrates to adaptive immunity by Toll-like
receptors (TLRs). Another function of TLRs is to work in sterile inflammation
to ligands derived from damaged cells, which are not usually present in the
extracellular environment. Thus, TLRs have very important interferences in the
pathogenesis of inflammatory and immune diseases. The discovery of TLRs has
transformed our approach to immunology and related diseases.