Affiliations: Department of Pediatrics and Neurology, University of Florida College of Medicine, Gainesville, FL, USA | Department of Pediatrics, Division of Neurology, Boston University, Boston, MA, USA
Note: [] Corresponding author: Dr. Edgard Andrade, Clinical Assistant Professor, Department of Pediatrics, University of Florida Health Science Center, Gainesville, FL, USA. Tel.: +1 352 273 5778; Fax: +1 352 392 9802; E-mail: [email protected].
Abstract: Epileptic encephalopathies refer to a group of uncommon disorders usually presenting in the first days of life secondary to a congenital inborn error of the metabolism. This group of disorders may involve a dysfunctional protein, an enzymatic deficiency or an excess of a byproduct; usually due to a faulty metabolic pathway. Several classifications have been coined in the past. In this article, we have reviewed the most common epileptic encephalopathies. Additionally, we are discussing a number of recently described channelopathies presenting with seizures early in life.
