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Determinants of Self-Stigma in People with Parkinson’s Disease: A Mixed Methods Scoping Review

Abstract

Background:

Self-stigma in people with Parkinson’s disease (PD) can substantially impact quality of life and possibilities for social participation. An integrative analysis of determinants of self-stigma has been lacking.

Objective:

We sought to explore which complementary insights from qualitative and quantitative studies, as well as from expert consultation, could be gained.

Methods:

An established mixed methods study design was employed to first conduct a mixed methods scoping review of published qualitative and quantitative literature, and then consult with experts to arrive at an exhaustive list of determinants of self-stigma after a thematic synthesis.

Results:

A total of 87 unique determinants of self-stigma were identified. Quantitative studies and expert consultations mainly identified personal determinants of people with self-stigma (e.g., age, anxiety, or apathy). In contrast, qualitative studies identified social situations associated with self-stigma (e.g., joint meals of people with typical PD with others). Notably, self-stigma of people with PD was found to be particularly salient in unfamiliar places, at the working place or in contact with people without PD. Across methods, cognitive impairment, tremor, and abnormal walk and unsteady gait, respectively, were associated with self-stigma.

Conclusion:

The mixed method study design yielded complementary insights, but also factors commonly associated with self-stigma across methods. Future prioritization exercises may gain further insights into self-stigma of people with PD. Facilitating social encounters by both addressing needs of affected people and raising knowledge and public awareness may improve quality of life in people with PD.

INTRODUCTION

The clinical symptoms of a person with typical Parkinson’s disease (PD) as described first by Dr. James Parkinson in 1817 include facial masking, the stooped posture, clenched and trembling arms, and shuffling gait [1]. These symptoms connote deformity and disability as the sociologist Nijhof [2] described in her research. Such typical PD manifestations are a root cause of stigmatization as they counteract social norms about normal behavior in a healthy social community [2]. More specifically, if in a social situation an unacquainted person shows behavior that deviates negatively from the expected stereotypical behavior of a healthy person, the behavior will be interpreted as sign of impairment. Typical PD symptoms can thus be considered as symbols associated with stigma if they are discrediting (discriminatory stimuli) and associated with a negative stereotype, for instance, if these symptoms correspond to typical behavior of a person under the influence of alcohol [3, 4]. The appearance (e.g., unsteady gate) is misattributed to be the result of alcohol misuse instead of a typical symptom of PD.

This process of stigmatization of PD symptoms can become internalized by the person affected by PD if they are aware of common misattributions of PD symptoms and exhibit or are anticipating exhibiting symptoms or behaviors commonly associated with undesirable stereotypes.

According to an international meta-analysis, self-stigma in people with typical PD was the dimension most significantly affected compared to the other dimensions of the Parkinson’s disease Questionnaire (PDQ39) [5]. Self-stigma has important consequences for overall quality of life and social participation for affected persons. In particular, self-stigma plays a significant role in determining whether and how effectively affected persons cope with typical PD [6]. Also, people with typical PD can feel incapable of meeting minimal social norms of interpersonal behavior which are important for creating and sustaining relationships with family, friends, coworkers, and others in their social environment [7]. Consequently, people with typical PD might withdraw from a public into a private world when they can no longer hide their symptoms [2, 8]. Notably, swallowing difficulties often induce isolation of people with typical PD as they may not be able to participate in joint meals which serve important social functions [9]. Self-stigma was reported as a determinant of depression [10] and as a key determinant of the quality of life of people with typical PD [8]. Moreover, a user-informed prioritization exercise confirmed self-stigma being one research priority defined by people with typical PD [11]. Thus, research on stigma has been identified as vital effort to enable people with typical PD to lead decent lives in the community [12]. Finally, knowledge on the underlying causes of stigma enables the development of effective nursing interventions to prevent or manage self-stigma of people with typical PD.

Despite numerous studies with qualitative and quantitative research designs, an integrative analysis of determinants of self-stigma in people with typical PD has been lacking. Therefore, the present study aims to summarize determinants of self-stigma, and sought to explore which complementary insights from qualitative and quantitative studies, as well as from expert consultation, could be gained regarding the determinants of self-stigma in people with PD [13]. Furthermore, the rationality of currently applied single-method approaches, i.e., literature review of quantitative studies will be explored. The following questions were addressed: What contextual determinants, that is, environmental and personal determinants and what body functions and -structure, activity and participation are associated with self-stigma in people with typical PD? Do qualitative and quantitative studies, and expert consultations, address different aspects of determinants of self-stigma?

MATERIALS AND METHODS

According to the Classification of Functioning, Disability and Health (ICF)-framework, we defined contextual determinants as environmental determinants, that is, the physical, social and attitudinal environment in which people live and conduct their lives, and personal determinants, “which include gender, age, coping styles, social background, education, profession, past and current experience, overall behavior pattern, character and other determinants that influence how disability is experienced by the individual.” [14] We defined body structure as “anatomical parts of the body such organs, limbs and their components”, activity as the “execution of a task or action by an individual.”, and participation as “involvement in life situations.” [14]. The development of our mixed methods study design was based on previous work of the PARADISE (Psychosocial fActors Relevant to BrAin DISorders in Europe) consortium [15]. The PARADISE consortium applied a mixed methods study design to generate a pool of psychosocial difficulties and environmental determinants relevant for brain disorders.

Mixed methods scoping review

According to the descriptive aim, the information about the risk of bias would not have influenced data synthesis. An assessment of methodological limitations or risk of bias of the evidence included within a scoping review is generally not performed [16]. Consequently, the method of a scoping review was chosen.

On 22 July 2020, we performed the mixed methods scoping review following the methodology of the JBI reviewer’s manual for mixed-methods systematic reviews [13] and scoping reviews [16] in the databases PubMed, CINAHL, and the Cochrane Library. No review protocol was registered in advance.

As recommended by Lizarondo et al. [13], a three-step search strategy was applied. An initial limited search for stigma and Parkinson’s disease in two databases (PubMed, CINAHL) identified no existing mixed methods literature reviews on the topic. This initial search was followed by an analysis of the words contained in the title and abstract of retrieved papers, and of the index terms of the articles to inform our search strategy [16]. Accordingly, MeSH and free-text terms (including spelling variants, synonyms, and truncation) were collected to identify appropriate search terms for the two search blocks typical PD and self-stigma. The following keywords for self-stigma were identified: Stigma*, Self Concept*, Self-Perception*, Perception* self, Self Esteem*, embarrass*, shame, guilt*, humiliat*, degradat*, discredit*, disesteem, dishonor. The asterisk * replaces any number of characters. The truncation process captured variations, that is, terms with the same word stem (e.g., stigma, stigmatization, stigmatisation, stigmatizing, stigmata, . . .). Search strategies were customized for each database. A search across all included databases using all keywords and index terms was done. Finally, we searched the reference lists of other reviews [17–20] for additional sources. The complete CINAHL search strategy is included in the Supplementary Material. The applied in- and exclusion criteria are illustrated in Table 1.

Table 1

In- and exclusion criteria in the mixed-methods scoping review

VariableInclusion criteriaExclusion criteria
ContentpPopulationAge of 18 years and more, Typical Parkinson’s disease diagnosed according to the MDS diagnostic criteriaAge of less than 18 years
No diagnosis of typical PD
No humans
EExposureDeterminants associated with self-stigma Quantitative part: statistical significance (p < 0.05)Articles not reporting the investigation of determinants associated with self-stigma
OOutcomeSelf-stigma
FormDesignQuantitative studies: Epidemiological studies measuring a statistical association between at least two variables (cohort, case-control-study, analytical cross-sectional study, RCTs, CCTs).Articles without empirical data (editorials, reviews, protocols, and studies reporting the psychometric validation of an instrument).
Qualitative studies: Studies that focus on qualitative data including, but not limited to, designs such as phenomenology, grounded theory, ethnography, and descriptive qualitative studies that describe the experience.
SettingNo restrictionsNo restrictions
Time frameNo restrictionsNo restrictions
LanguageNo restrictionsNo restrictions
CultureNo restrictionsNo restrictions

Expert consultation

The authors suspected that patients were not aware of all determinants of self-stigma. Consequently, the clinical expert opinion of six clinicians, neuropsychologists, and PD nurses involved in the Luxembourg Parkinson Study and thus in daily contact with people with PD and their family and friends [21] was consulted according to the PARADISE consortium [15].

Thematic synthesis

As illustrated in Fig. 1, we started thematic synthesis by predefining the categories. Operational definitions for each category were determined by the ICF-framework [14]. After reading the articles and highlighting all text that on first impression appears to represent a category, we coded all highlighted passages, i.e., defined line by line the keywords describing the meaning and content. In the third step, we looked for similarities and differences between the defined keywords. Finally, similar determinants were grouped and named by a descriptive theme.

Fig. 1

Exemplar process from “Definition of ICF-levels as categories” to “Assignment of ICF levels to descriptive themes” (thematic synthesis).

Exemplar process from “Definition of ICF-levels as categories” to “Assignment of ICF levels to descriptive themes” (thematic synthesis).

Data integration

We performed a so-called thematic synthesis of the data [22] separately, before integrating the results of these syntheses in an overall qualitative synthesis in form of side-by-side comparisons. More specifically, we integrated the different sources according to a results-based convergent mixed-methods synthesis design [23] (Fig. 2). This approach allowed to determine whether the quantitative and qualitative data address different aspects of self-stigma and to determine in what ways the results confirm, disconfirm, or expand each other [24].

Fig. 2

Results-based convergent mixed-methods synthesis design according to Hong et al. [25].

Results-based convergent mixed-methods synthesis design according to Hong et al. [25].

RESULTS

As Fig. 3 shows, after removing duplicates, we identified 28 quantitative [26–53] and 23 qualitative studies [2, 6, 8, 9, 54–68] through the mixed methods scoping review.

Fig. 3

Study selection process for the mixed methods scoping review according to the PRISMA-ScR reporting guideline [25].

Study selection process for the mixed methods scoping review according to the PRISMA-ScR reporting guideline [25].

As indicated in Fig. 4, in total 106 determinants were identified in the mixed methods study design. 19 determinants were identified by multiple data sources.

Fig. 4

Number of determinants identified by data source.

Number of determinants identified by data source.

Quantitative cross-sectional studies were applying heterogenic definition and operationalization for determinants and the outcome. Only one quantitative study [46] investigated the self-stigma as a primary outcome.

Figures 5–7 synthesize identified determinants according to the ICF-framework [14].

Fig. 5

Body functions and structure, activity, and participation identified according to the ICF-framework [14].

Body functions and structure, activity, and participation identified according to the ICF-framework [14].
Fig. 6

Environmental determinants identified according to the ICF-framework [14].

Environmental determinants identified according to the ICF-framework [14].
Fig. 7

Personal determinants identified according to the ICF-framework [14].

Personal determinants identified according to the ICF-framework [14].

To better understand the nature of self-stigma, common misattributions of PD symptoms were collected. Atypical behavior may be misinterpreted as:

  • Intoxication from alcohol or street drugs [6, 58, 69];

  • Expression of negative emotions, e.g., anger, nervousness, or, from the partner’s perspective, having fallen out of love [2, 58], grumpy, reticent [6, 66, 69];

  • Expression of cognitive impairment or psychological disorder (e.g., depression) [9, 66, 68–70];

  • Expression of a physical state, e.g., frailty, pain, being physically handicapped (e.g., from dyskinesia) [2, 8, 55, 58, 66, 69], there’s something wrong [55, 68];

  • Socially deviant behavior (e.g., being a thief) [2, 66].

Tables 2–4 list all determinants of self-stigma and the source of data in a joint display.

Table 2

Identified body functions and structure, activity, and participation associated with self-stigma1

Quantitative StudiesQualitative StudiesExpert consultation
[43] (1x)[30] (1x)[40] (1x)[49] (1x)[47] (3x)[29] (1x)[37] (1x)[45] (1x)[28] (3x)[55] (4x)[56] (3x)[57] (1x)[59] (1x)[61] (4x)[63] (1x)[65] (3x)[67] (1x)[71] (3x)[72] (3x)[60] (2x)[6] (5x)[58] (7x)[9] (3x)[62] (4x)[64] (1x)[2] (17x)[66] (6x)[68] (4x)[8] (3x)[20] (4x)[70] (4x)(5x)
Atypical Behavior in Social Situations
1. Abnormal posture (4x)c,eXXXX
2. Abnormal walk/ unsteady gait (8x)d,fXXXXXXXX
3. Choking (1x)c,eX
4. Don’t eat properly (1x)c,eX
5. Drooling (3x)d,fXXX
6. “drunken” language (1x)b,eX
7. Dyskinesia (6x)d,fXXXXXX
8. Falls (2x)c,eXX
9. Freeze, Bradykinesia (3x)d,fXXX
10. Incontinence (2x)b,c,d,eXX
11. On-/Off Phenomena (2x)d,fXX
12. Tremor (13x)d,fXXXXXXXXXXXXX
Reduced Independency
13. Inability to walk (1x)c,eX
14. Inability to get up from a chair (1x)c,eX
15. Cut food (4x)c,eXXXX
16. Eat meals requiring fine motor skills (1x)c,eX
17. Get something out of the purse (2x)c,eXX
18. Have towels to use as a bib (1x)c,eX
19. Need plastic cover to wash hands (1x)c,eX
20. Need someone to clean me (1x)c,eX
21. Put pieces of bread into the mouth (1x)c,eX
22. Impaired Activities of Daily Living (2x)aXX
23. Remove top of the bottle (1x)c,eX
24. Writing problems (3x)c,eXXX
Delays in Social Situations
25. Cause disruption (1x)c,eX
26. Couldn’t keep up with the old group (3x)c,eXXX
27. Delayed reactions (1x)c,eX
28. Remain at the table long after others had finished (1x)c,eX
29. Slowed gait (walking speed) (2x)c,eXX
Determinants Impairing Oral Communication
30. Abnormal oral language (5x)d,fXXXXXX
31. Cognitive impairment manifesting (7x)d,fXXXXXXXX
32. Further difficulties with conversations (3x)d,fXXX
33. Hallucinations (2x)c,eXX
34. Lack of facial expression (5x)c,eXXXXX
35. No fit between one’s situation and facial expression (3x)c,eXXX
36. No fit between own and other-perceived problems (2x)c,eXX

1(... x) = Sum of identified studies / determinants per column / row, aQuantitative studies only, bExpert consultation only, cQualitative studies only, dAt least two different data and methods, eQualitative studies and / or expert consultation without confirmation by quantitative studies, fQualitative studies and / or expert consultation being confirmed by quantitative studies.

Table 3

Identified environmental determinants of self-stigma1

Quantitative StudiesQualitative StudiesExpert Consultation
Identified environmental determinants associated with self-stigma[26] (1x)[32] (1x)[31] (1x)[35] (1x)[38] (1x)[39] (1x)[41] (1x)[55] (2x)[54] (1x)[61] (1x)[65] (1x)[72] (5x)[6] (3x)[58] (4x)[9] (1x)[2] (6x)[66] (8x)[68] (5x)[8] (2x)[72] (1x)(1x)
Others’ Knowledge about the Disease
37. Association between typical PD and severe dementia in the public’s eyes (1x)c,eX
38. Others are not aware of symptoms of typical PD (3x)c,eXXX
39. People know it’s connected to the brain (1x)c,eX
Social Situations
40. All people stare at me (2x)c,eXX
41. Aquatic physiotherapy (1x)aX
42. Body awareness training (1x)aX
43. Face people when one’s eating (3x)c,eXXX
44. Group exercise and motivational telephone counseling (1x)aX
45. Have to answer “What has happened to you?” (1x)c,eX
46. People feel sorry for them (2)c,eXX
47. People feel they have to help them (2x)c,eXX
48. Tango Argentino (1x)c,eX
When
49. Always (1x)c,eX
50. Deep Brain Stimulation (1x)aX
51. During the day (1x)c,eX
Where: In the “Outside World”/ In Public
52. At work (3x)c,eXXX
53. On a wedding (1x)c,eX
54. Rural life settings (2x)d,fXXX
55. Unfamiliar places, In the streets, Bus, Restaurant, Service providers (6x)c,eXXXXXX
Who: Others Who Don’t Have Typical PD
56. A large group (1x)c,eX
57. Coworkers (4x)c,eXXXX
58. Family: People who know who they are inside (1x)c,eX
59. Friends (1x)c,eX
60. Kids (2x)c,eXX
61. Neighbors (2x)d,eXX
62. Support group (2x)d,eXX
63. Visitors (2x)c,eXX
Characteristics of the Rater of the PDQ-39
64. Completion of the questionnaire by the caregiver (1x)aX

1(... x)=Sum of identified studies / determinants per column / row, aQuantitative studies only, bExpert consultation only, cQualitative studies only, dAt least two different data and methods, eQualitative studies and / or expert consultation without confirmation by quantitative studies, fQualitative studies and / or expert consultation being confirmed by quantitative studies.

Table 4

Identified personal determinants of self-stigma1

Quantitative StudiesExpert Consultation
Identified personal determinants associated with self-stigma[32] (1x)[33] (1x)[34] (1x)[36] (1x)[42] (1x)[46] (2X)[49] (7X)[28] (2x)[52] (10x)[48] (1x)[51] (2x)[44] (1x)[53] (2x)[38] (1x)[39] (1x)[37] (1x)[27] (1x)[50] (1x)(15x)
Characteristics of the Person with Typical PD
65. Age (3x)aXXX
66. Anxiety (2x)d,fXX
67. Apathy (1x)b,eX
68. Awareness of the stigma symbols (1x)b,eX
69. Coping (1x)b,eX
70. Country of residence (1x)aX
71. Depression (3x)d,fXXX
72. Educational attainment (1x)b,eX
73. Female (2x)d,fXX
74. Income (1x)b,eX
75. Self-awareness (1x)b,eX
76. Malnutrition (2x)aXX
77. Nationality (1x)b,eX
78. Neuroticism (1x)aX
79. No comorbidity (1x)aX
80. Optimism (1x)aX
81. (Previous) occupation before typical PD required fine motor skills or communication skills (1x)b,eX
82. Psychiatric disease (1x)aX
83. Self-esteem (1x)aX
84. Social status, social engagement level, social activity (1x)b,eX
85. Stress (1x)aX
86. Survey language (1x)aX
87. Type D personality (1x)aX

1(... x) = Sum of identified studies / determinants per column / row, aQuantitative studies only, bExpert consultation only, cQualitative studies only, dAt least two different data and methods, eQualitative studies and / or expert consultation without confirmation by quantitative studies, fQualitative studies and / or expert consultation being confirmed by quantitative studies.

While quantitative studies identified most of the personal determinants, qualitative data revealed most of the subjective, patient-reported determinants related to the environment, body functions and structure, activity, and participation.

Most determinants were identified by qualitative studies only. Accordingly, 51%(44/87) of all determinants would not have been identified by excluding qualitative research. Furthermore, only 22%of the determinants (13/59) identified by qualitative studies and expert consultation were confirmed by quantitative studies.

Finally, three determinants were identified across all data and methods: Manifestation of cognitive impairment, tremor, and abnormal walk or unsteady gait, respectively.

DISCUSSION

Summary of findings

With a mixed methods scoping review of quantitative and qualitative studies, and expert consultation integrated with qualitative synthesis, a total of 87 determinants of self-stigma were identified.

As an overall finding, personal determinants (e.g., age, anxiety, or apathy) were identified by the quantitative studies and the expert consultation, while qualitative studies did not reveal any personal determinants. This supports our suspicion that patients are not always aware of personal determinants of self-stigma. In contrast, quantitative studies identified fewer symptoms and behaviors associated with self-stigma compared with qualitative findings.

As an insight from the qualitative studies, self-stigma arises from both other-perceived and only self-perceived symptoms and behaviors, thus, visible marks and invisible stains as described by Cumming and Cumming [74] are both important. This result confirms their theory stating self-stigma acquires its meaning through the emotion it generates within the person bearing it and the feeling and behavior toward him. Nijhof [2] concluded that self-stigma is always perceived in contact with the “outside world”, that is, with people who are not part of the family. Similarly, our work identified social situations associated with self-stigma, for example, joint meals of people with typical PD with others, and the person with PD perceiving the other person as feeling sorry for them, staring at them (questioningly). In particular, self-stigma is salient in unfamiliar places and at the working place. Furthermore, people with typical PD are perceiving self-stigma when they are around persons who don’t have typical PD like friends, visitors, neighbors, coworkers, service providers, or children. Consequently, our results confirm statements by Major and O’Brien [73] and Cumming and Cumming [74]: Self-stigma originates in the social context instead in the person, i.e., is reinforced in interaction with others.

Implications for personalized interventions and awareness campaigns

As the PD-related knowledge of others in social encounters or in public is an important factor associated with self-stigma, the present results can be integrated in communication campaigns informing about the identified factors (e.g., impaired communication) to increase awareness about typical symptoms in PD. Further, personalized support for people with PD may also be helpful to reduce self-stigma. Support groups like Parkinson Associations seem to be an important resource for people with typical PD and should be facilitated. Communication guidance enabling people with PD to speak more openly about their symptoms with others may facilitate social encounters with unacquainted persons and being in the “outside world”.

Strengths and limitations of the study

Previous reviews of qualitative studies [17–20] described experiences of self-stigma by people with typical PD. The integration of qualitative and quantitative research is one strength of the present study. Factors that were identified through more than one method (qualitative study, quantitative study, or expert consultation) can be considered to be validated through this approach. Other factors that were identified by only one of the methods may merit attention also through other research methods. More than 50%of all factors would not have been identified by excluding qualitative research, showing the importance of the consideration of multiple sources and types of data when creating an overview of the determinants of self-stigma. The need for further quantitative investigations of determinants of self-stigma is highlighted by the fact that less than 20%of all factors identified by qualitative studies and expert consultation were confirmed by quantitative studies. Furthermore, the detailed documentation of our review enables reproducibility, whereas some of the recent reviews, such as Angulo et al. [18] have preferred to review the literature in a narra-tive way.

The mixed methods study design employed here is less exhaustive than other forms of research [16], however it has enabled us to arrive at an important map of existing evidence on determinants of self-stigma. Thus, the applied criteria of a mixed methods scoping review described by Booth and colleagues [75] and [16] are less rigorous than those of classical systematic reviews (i.e., no formal quality assessment, no grey literature, no search for unpublished studies). The restricted use of published data for the thematic synthesis of qualitative studies might have resulted in a lack of identification of some factors. Adding the method of expert consultation however further enriched the collection of evidence through identification of further unique factors.

From the qualitative synthesis, it remains unclear which of the several identified factors are most strongly related to self-stigma, as a prioritization of factors should be informed by persons living with PD and their caregivers. Consequently, further systematic prioritization of the identified determinants of the self-stigma should be investigated in future studies. In addition, typical misattributions related to the three motor- and non-motor symptoms (i.e., manifestation of cognitive impairment, tremor, and abnormal walk/unsteady gait) that were identified across all methods need to be explored by further research.

From the qualitative synthesis, factors that were only identified by qualitative research or expert consultation would merit further attention in quantitative research in order to better understand the phenomenon of self-stigma. For example, personal characteristics such as self-awareness, and demographic characteristics such as income and thus possible health inequities in self-stigma, could inform interventions. The present study, through the comprehensive collection of determinants of self-stigma, provided an opportunity to gain a better understanding of the phenomenon of self-stigma. The mixed method study design combined with expert consultation yielded complementary insights, but also common factors that were associated with self-stigma across methods. Future research may gain further insights into the differential importance of these factors by mixed-method and user-informed studies to allow a prioritization of the numerous identified determinants of self-stigma. Facilitating social encounters by both addressing needs of affected people and raising knowledge and awareness of the public may reduce self-stigma and improve quality of life in people with PD.

ACKNOWLEDGMENTS

We would like to thank all participants of the Luxembourg Parkinson’s Study for their important support to our research. Furthermore, we acknowledge the joint effort of the National Centre of Excellence in Research on Parkinson’s Disease (NCER-PD) Consortium members from the partner institutions Luxembourg Centre for Systems Biomedicine, Luxembourg Institute of Health, Centre Hospitalier de Luxembourg, and Laboratoire National de Santá generally contributing to the Luxembourg Parkinson’s Study as listed here: Geeta ACHARYA, Gloria AGUAYO, Myriam ALEXANDRE, Dominic ALLEN, Wim AMMERLANN, Maike AURICH, Federico BALDINI, Rudi BALLING, Peter BANDA, Katy BEAUMONT, Regina BECKER, Camille BELLORA, Guy BERCHEM, Daniela BERG, Fay BETSOU, Sylvia BINCK, Alexandre BISDORFF, Dheeraj BOBBILI, Sandy BOLY, Kathrin BROCKMANN, Jessica CALMES, Lorieza CASTILLO, Nico DIEDERICH, Rene DONDELINGER, Daniela ESTEVES, Guy FAGHERAZZI, Tessy FAUTSCH, Jean-Yves FERRAND, Ronan FLEMING, Manon GANTENBEIN, Thomas GASSER, Piotr GAWRON, Lars GEFFERS, Virginie GIARMANA, Enrico GLAAB, Clarissa GOMES, Nikolai GONCHARENKO, Járôme GRAAS, Mariela GRAZIANO, Valentin GROUES, Anne GRÜNEWALD, Wei GU, Gaël HAMMOT, Anne-Marie HANFF, Linda HANSEN, Maxime HANSEN, Hulda HARALDSDÖTTIR, Laurent HEIRENDT, Estelle HENRY, Sylvia HERBRINK, Johannes HERTEL, Sascha HERZINGER, Michael HEYMANN, Karsten HILLER, Geraldine HIPP, Michele HU, Laetitia HUIART, Alexander HUNDT, Nadine JACOBY, Jacek JAROSLAW, Yohan JAROZ, Pierre KOLBER, Rejko KRÜGER, Joachim KUTZERA, Pauline LAMBERT, Zied LANDOULSI, Catherine LARUE, Roseline LENTZ, Inga LIEPELT, Robert LISZKA, Laura LONGHINO, Victoria LORENTZ, Paula Cristina LUPU, Clare MACKAY, Walter MAETZLER, Katrin MARCUS, Guilherme MARQUES, Tainá MARQUES, Jan MARTENS, Piotr MATYJASZCZYK, Patrick MAY, Deborah MCINTYRE, Francoise MEISCH, Myriam MENSTER, Guilherme MEYERS, Maura MINELLI, Michel MITTELBRONN, Brit MOLLENHAUER, Kathleen MOMMAERTS, Carlos MORENO, Friedrich MÜHLSCHLEGEL, Romain NATI, Ulf NEHRBASS, Sarah NICKELS, Beatrice NICOLAI, Jean-Paul NICOLAY, Alberto NORONHA, Wolfgang OERTEL, Marek OSTASZEWSKI, Sinthuja PACHCHEK, Claire PAULY, Laure PAULY, Lukas PAVELKA, Magali PERQUIN, Rajesh RAWAL, Dorothea REITER, Eduardo ROSALES, Isabel ROSETY, Kirsten RUMP, Estelle SANDT, Venkata SATAGOPAM, Marc SCHLESSER, Margaux SCHMITT, Sabine SCHMITZ, Susanne SCHMITZ, Reinhard SCHNEIDER, Jens SCHWAMBORN, Alexandra SCHWEICHER, Amir SHARIFY, Kate SOKOLOWSKA, Lara STUTE, Ines THIELE, Hermann THIEN, Cyrille THINNES, Joana TORRE, Christophe TREFOIS, Jean-Pierre TREZZI, Johanna TROUET, Michel VAILLANT, Daniel VASCO, Maharshi VYAS, Richard WADE-MARTINS, Femke WAUTERS, Paul WILMES

This work was supported by grants from the Luxembourg National Research Fund (FNR) within the National Centre of Excellence in Research on Parkinson’s disease [NCERPD(FNR/NCER13/BM/11264123)]. RK has received research grants from Fonds National de Recherche de Luxembourg (FNR) as Coordinator of the National Centre for Excellence in Research on Parkinson’s disease (NCER-PD) and within the PEARL Excellence Programme (FNR/P13/6682797/Krüger), the Michael J. Fox Foundation (ID: 1480), and the European Union’s Horizon 2020 research and innovation program (WIDESP-READ; CENTRE-PD; grant agreement no. 692320).

CONFLICT OF INTEREST

The authors have no conflict of interest to report.

SUPPLEMENTARY MATERIAL

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