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Article type: Short Communication
Authors: Gryc, Wojciecha; b | Roberts, Kathryn A.a; b | Zabetian, Cyrus P.a; b | Weintraub, Danielc; d; e | Trojanowski, John Q.f; g | Quinn, Joseph F.h; i | Hiller, Amie L.h; i | Chung, Kathryn A.h; i | Poston, Kathleen L.j | Yang, Lauricej | Hu, Shu-Chinga; b | Edwards, Karen L.k | Montine, Thomas J.l | Cholerton, Brenna A.l; *
Affiliations: [a] Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA | [b] Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA | [c] Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA | [d] Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA | [e] Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA | [f] Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA | [g] Institute on Aging, University of Pennsylvania, Philadelphia, PA | [h] Portland Veterans Affairs Medical Center, Portland, OR, USA | [i] Department of Neurology, Oregon Health and Science University, Portland, OR, USA | [j] Department of Neurology and Neurological Sciences, Stanford School of Medicine, Palo Alto, CA, USA | [k] Department of Epidemiology, University of California, Irvine, School of Medicine, Irvine, CA, USA | [l] Department of Pathology, Stanford University School of Medicine, Palo Alto, CA, USA
Correspondence: [*] Correspondence to: Brenna Cholerton, PhD, Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive L-235, Stanford, CA 94305, USA. Tel.: +1 253 226 4842; E-mail: [email protected].
Abstract: Neuropsychiatric symptoms are common in Parkinson’s disease (PD). We investigated the relationship between neuropsychiatric symptoms and current and future diagnosis of PD dementia (PDD). Individuals with PD who had a study partner were enrolled (n = 696). Study partners were administered the Neuropsychiatric Inventory or Neuropsychiatric Inventory Questionnaire at baseline. Participants were assigned a cognitive diagnosis at baseline and follow up visits. Hallucinations were significantly associated with a diagnosis of PDD cross-sectionally (p < 0.001) and with shortened time to dementia longitudinally among initially nondemented participants (n = 444; p = 0.005). Screening for hallucinations may be useful for assessing risk of dementia in participants with PD.
Keywords: Behavioral symptoms, cognition, dementia, hallucinations, Parkinson’s disease
DOI: 10.3233/JPD-202116
Journal: Journal of Parkinson's Disease, vol. 10, no. 4, pp. 1643-1648, 2020
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