Affiliations: Department of Neurology and National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China
Correspondence to: Dr. Jian Wang and Dr. Jintai Yu, Department of Neurology and National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China. Tel.: +86 13321934789 (Jian Wang), +86 21 52888160 (Jintai Yu); Fax: +86 21 52888163 (Jian Wang), +86 21 62483421 (Jintai Yu); E-mails: [email protected] (Jian Wang) and [email protected] (Jintai Yu).
Note:  These authors contributed equally to this work
Abstract: Background:Parkinson’s disease with mild cognitive impairment (PD-MCI) or dementia (PDD) has been shown to be correlated with poor quality of life (QoL). The association between specific cognitive domains and QoL is less clear. Objective:To determine how the cognitive domains affect QoL in different cognitive states in PD. Methods:We recruited 600 PD patients, including 185 PD patients with normal cognition (PD-NC), 336 PD-MCI patients, and 79 PDD patients. All patients underwent a scale-based assessment (PDQ-39) for QoL, as well as clinical evaluations and neuropsychological tests. Results:Compared to PD-NC group, QoL became more impaired in the PD-MCI and PDD groups. Generalized linear model revealed that no neuropsychological test was significantly associated with QoL in PD-NC group; neuropsychological tests in attention and language domains were significantly associated with QoL in PD-MCI patients; neuropsychological tests in memory and language domains were significantly associated with QoL in PDD patients. Conclusions:Cognitive domains contribute differently to QoL in PD. These findings may prompt clinicians to target specific cognitive domains for improving QoL in the PD patients.
Keywords: Parkinson’s disease, mild cognitive impairment, dementia, quality of life