Understanding the regional needs and available healthcare resources to treat Parkinson’s disease (PD) is essential to plan appropriate future priorities. The International Parkinson and Movement Disorder Society (MDS) Task Force for the Middle East was established to raise awareness and promote education across the region on PD and other movement disorders. Broadly, the task force encompasses the countries of the Middle East but has included North Africa and South Asia as well (MENASA).
To create a list of needs and priorities in the advancement of PD in MENASA countries based on consensuses generated by the MDS task force for the Middle East.
A Strengths Weaknesses-Opportunities-Threats (SWOT) analysis was conducted by the task force members to generate consensus about PD care this region.
Eight overarching principles emerged for the consensus statement on current needs: more movement disorders specialists, multidisciplinary care, accurate epidemiologic data, educational programs, availability of drugs, and availability of more advanced therapy, enhanced health care resources and infrastructure, and greater levels of awareness within the general population and among health care professionals.
This pilot study sheds light on unmet needs for providing care to people with PD in the MENASA region. These data offer directions on priorities to increase awareness of PD, to develop better infrastructure for research and management of PD, to foster healthcare policy discussions for PD and to provide educational opportunities within these countries.
Neurodegenerative disorders such as Parkinson’s disease (PD) are largely diseases of older adults . As life expectancy increases across the globe , the prevalence of such diseases is expected to increase. There is evidence of regional and ethnic differences  in not only the prevalence of PD, but also in disease manifestations. This may include the age of onset, the occurrence of motor fluctuations, cognitive dysfunction, and rates of impulse control disorders. Exogenous factors, such as regional differences in availability and use of PD medications, add further to the heterogeneity of PD across treatment locales . Increased mortality from PD has been seen globally, and this is not entirely accounted for by the increased prevalence of PD .
Understanding the regional needs to treat PD and other neurodegenerative disorders is essential to appropriately prioritize research and public health policies that accurately project scientific priorities. This helps facilitate allocating healthcare needs and costs for the given population over time. Therein lies the mission of the International Parkinson and Movement Disorder Society (MDS) Task Force for the Middle East. It was established to raise awareness and education across the region on PD and other movement disorders. Broadly, the task force encompasses the countries of the Middle East, North Africa, and South Asia (MENASA; Table 1). These are a heterogeneous group of predominantly developing countries, the populations of which constitute one-third of the global population. They share some characteristics that allow them to be considered broadly as a group and pose the opportunity to study determinants of PD in these non-Western regions, including epidemiological, environmental and genetic contributors [6, 7].
|Country population (in 2015; thousands) ||Number of neurologists *||International Parkinson and Movement Disorder Society Membership, N (% of total members, 2017)||Age-adjusted prevalence and/or Prevalence in designated age strata /100,000|
|Algeria||39,872||83 –250 ||2 (0.03)|
|Egypt||93,778||500 –1800 ||65 (0.84)||Assuit governate: 2,748 in ≥50 years; 7,263 in ≥70–79 years in 2010 .|
|Red Sea Governate: 452.1 in 2009-2012 in ≥40 /522,25 in 60–70 age group; 3554.5 in ≥80 .|
|Qena governate: 15,094 in ≥75 years in 2013 |
|Iran||81,672||550 ||23 (0.30)|
|Iraq||36,116||61 –95 ||10 (0.13)|
|Israel||8,065||300 ||30 (0.39)||942 in ≥60 years in 1998 |
|Jordan||9,159||38 –60 ||28 (0.36)|
|Kuwait||3,936||7 –40 ||2 (0.03)|
|Lebanon||5,851||100–120 ||5 (0.06)|
|Libya||6,235||21–40 ||0 (0)||285.1 in >50 age group in 1982-1984 |
|Morocco||34,803||50 –100 [83, 88]||15 (0.19)|
|Oman||4,200||10–20 ||0 (0)|
|Qatar||2,482||4 –13 ||0 (0)|
|Saudi Arabia||31,557||25 –80 ||16 (0.21)|
|State of Palestine||4,663||No data could be found||1 (0.01)||477.32 > 65 years; 12.29 < 65 years (reported in 2010, based on drug prescription data) |
|Sudan||38,648||21–40 ||2 (0.03)|
|The Syrian Arab Republic||18,735||>300 ||0 (0)|
|Tunisia||11,274||45 –100 ||10 (0.13)||216 per 100,000 in ≥40 years and 296≥50 years in 1985 .|
|United Arab Emirates||9,154||41–60 ||9 (0.12)|
|Yemen||26,916||45 ||0 (0)|
|Afghanistan||33,736||2 ||1 (0.01)|
|Bahrain||1,372||4 –10 ||0 (0)|
|Bangladesh||161,201||86 ||52 (0.67)|
|Bhutan||787||0 ||0 (0)|
|India||1,309,054||1200 ||383 (4.93)||Bangalore district: age-adjusted 76.0 in 2004 .|
|Kolkata: age-adjusted 52.85 in 2003 to 2007 .|
|Parsis of Mumbai: age-adjusted 192 |
|Nepal||28,656||7 ||10 (0.13)|
|Pakistan||189,381||32 ||78 (1.0)||Khyber Pakhtunkhwa province: 1,700 in ≥75 years in 2011 |
|Sri Lanka||20,714||16 ||32 (0.41)|
*Time period as per referenced article. Empty cells indicate no data available.
Overall, twenty of the MENASA countries are Arab, defined broadly as countries where the primary official language is Arabic. The Arab countries not only share a language, but the genetic background, social structure, and culture. The World Health Organization grouping for these countries is “The Middle East and North Africa” (MENA). The remaining 8 countries are South Asian (SA) countries that are grouped by the United Nations. The task force recognizes the inclusion of these countries as well, given their geographic proximity to the greater Middle East, and similarities including developing economies, the emergence of diseases of older adulthood, and some degree of overlap in cultural and religious beliefs. This is in keeping with other world organizations grouping countries with similar economic and regional needs together, as with the Middle East, North Africa, Afghanistan, and Pakistan (MENAP) designation by International Monetary Fund (IMF) . Any broad generalizations concerning PD in the MENASA countries in the aggregate are made with caution and the caveat that there are regional and country-specific patterns to be considered.
This manuscript aims to create a list of needs and priorities in the advancement of PD in MENASA countries based on consensuses generated by the MDS task force for the Middle East. To frame the consensus and put it into context, we first provide an overview of the existing literature regarding epidemiology, disease manifestations, and unique genetic considerations on PD in MENASA countries.
Needs assessment: identification and prioritization
A staged process was followed to generate a consensus statement about PD care in MENASA countries. The methodology applied to synthesize the assessed needs was adapted from that used previously by a European expert group in multiple sclerosis (MS) . In brief, the following steps were undertaken:
1) Taskforce members were asked to complete strength, weaknesses, opportunities, threats (SWOT) analysis about PD care in the MENASA countries. The SWOT analysis was based on pilot data obtained from a previously conducted MDS survey [10, 11]. The majority of the members who participated in the SWOT analysis are clinicians (n = 11), one is a specialist PD nurse, and another is a physiotherapist PD researcher. The two allied health professionals are from countries (Jordan and Saudi Arabia) where clinicians from the same countries are also members of the task force. Additionally, all members have extensive experience working with people with PD and are very knowledgeable of the current situation in their respective countries ; thus, this step was essential to provide needed data.
2) Following the SWOT analysis, members were invited to participate in 2 teleconferences and one face-to-face workshop, these occurred between February 2017 and October 2017. Discussions on the first teleconference, which was followed by the face-to-face workshop, focused on the SWOT analysis outcome as well as published literature. This cross-check method between the SWOT analysis and the literature overview helped to identify the most critical goals, unmet needs, and areas for development in PD care.
3) The second teleconference in particular, which was conducted at the end, focused on prioritizing critical goals and unmet needs of the consensus statement based on a voting system. This means the task force needs to establish what is considered a list of needs and priorities in the advancement of the Movement Disorders field in general and PD care in specific in the region. To accomplish this important step, each member of the task force was asked to use five votes. These votes can be allocated in any combination among the items listed in Table 2 (items were formulated based on the task force SWOT analysis and the survey results ). This process meant that multiple votes could be allocated to one item, and in this case, prioritization of relative item importance could be established.
|Potential Areas of development||Number of votes, N (%) (65 votes, 5 votes/person)|
|The need for more movement disorders’ specialists||14 (21.54)|
|Multidisciplinary care||9 (13.85)|
|Need for Accurate epidemiologic data||9 (13.85)|
|The need for more educational opportunities||7 (10.77)|
|Availability of more options of drugs||4 (6.15)|
|Availability of advanced therapies||4 (6.15)|
|Health care resources and infrastructure||4 (6.15)|
|Level of awareness among the general population and health care professionals||4 (6.15)|
|Commitment to research||2 (3.08)|
|Cost and reimbursement||2 (3.08)|
|PD centers of excellence||2 (3.08)|
|Regional and national movement disorders societies||2 (3.08)|
|Patients engagement and adherence||1 (1.54)|
|Networking with supporting organizations||1 (1.54)|
|Early referrals, diagnosis, and management||0 (0)|
|Better communication with stakeholders||0 (0)|
Each voting member had a total of 5 votes. Multiple votes for a single topic were allowed. Members who voted included 11 movement disorders’ specialists, one nurse specialist in PD and one physiotherapist researcher specialist in PD. Those members were representing 10 different countries.
Overview of PD epidemiology, genetic considerations, and disease manifestations
There are limited data on the epidemiology of PD in many MENASA countries (Table 1). Many data available from door-to-door epidemiologic studies conducted in MENASA countries are from decades prior. Incidence rate data were available for only 2 countries; PD incidence per 100,000 was 4.5 in Libya in 1982-1984 , and 5.71 in Kolkata, India in 2003 to 2007 . In the past decade, door-to-door studies on the prevalence of PD were found only for Egypt [14, 15]. Among South Asian countries, prevalence data for India are robust [16, 17], and some data were found for Pakistan  but not other countries.
As for the risk factors for PD in MENASA countries, age and male sex are risk factors for PD  (see Table 1), as seen in Western countries . Environmental risk factors associated with PD in the United States and Western Europe include pesticide exposure , well-water use, rural-dwelling and farming , and head injury , but these risk factors have yet to be ascertained in MENASA countries. Caffeine and tobacco product usage has been associated with a lower risk of PD but this also remains to be proven in non-Western populations [24, 25]. There are few studies on environmental risk factors for PD in MENASA countries. In many Arab countries, a large proportion of the population lives in rural regions where farming is ubiquitous. As in some studies in Western countries, one study in Egypt found a higher prevalence of PD among rural dwellers . One hypothesis is that a large proportion of the population chews on the leaves of Catha edulis (“Khat”) that has been theorized to cause dopaminergic cell toxicity and may be related to the development of parkinsonism . However, another study by the same group in the Assiut and Qena governates of Egypt found a higher prevalence in urban areas, where industrial toxins from factories may drain into the Nile river . This finding agrees with a large study in the USA (using a comprehensive population-based health care database) that demonstrated a substantially higher prevalence and incidence of PD in urban areas rather than in rural areas . In another example, a small case-control study in Uttar Pradesh, India found a higher prevalence of self-reported exposure to chemicals and well water drinking among PD cases, but not other factors identified in Western countries . On the other hand, a case-control study in Eastern India identified the following risk factors for PD: family history of PD, pesticide exposure, exposure to toxins other than pesticides and herbicides, and rural living . These and other data suggest that there may be some shared environmental risk factors for PD in MENASA countries, but there are likely differences as well. Indeed, given the known mediation of environmental risk factors for diseases by genetic factors [31–33], environmental risk factors for PD identified in Western countries are not necessarily generalizable to other regions of the world, and further studies in MENASA countries are essential.
Regarding genetic determinants or contributors to PD in MENASA countries, much work has focused on the high prevalence of the G2019S LRRK2 gene mutation in North African countries. While in most populations, mutations in the LRRK2 gene account for only about 1% of sporadic cases of PD, this mutation is more common in Ashkenazi Jews  and is especially common in the North African Berbers of Morocco, Tunisia, and Algeria . A small study suggested that this mutation is relatively prevalent in a Northern region of Egypt  but may be less common in other regions of the country , possibly due to the lower prevalence of Berbers in that region. On the other hand, G2019S LRRK2 mutations were not found to be common in one other Arab country where this has been studied, namely Saudi Arabia . Otherwise, data on the genetic epidemiology of PD in MENASA countries are limited. Populations of the MENASA countries are significantly under-represented in genome-wide association studies (GWAS) . In many MENASA countries, especially Arab countries, there are high rates of consanguinity among first cousins [40, 41]. Indeed, much insight into PD genetics has been gained from studying families originating in MENASA countries including Jordan [42–44], Sudan , and Palestine . Thus, the high rates of consanguinity in some MENASA countries, combined with the heterogeneous genetic constitution of the MENASA population that is distinct from Western countries, provide great impetus to study the genetic epidemiology of PD in MENASA countries [47, 48].
There are few studies on PD disease clinical manifestations in the MENASA regions. Information on differences between sporadic vs familial forms, age of onset, progression is limited. In one study from Saudi Arabia , 33.67% of cases studied were familial (defined as at least 1 first or second-degree relative with PD). Almost one-third of the familial cases were young-onset (<50 years), but pathogenetic mutations that account for 25–30% of young-onset PD in other populations were only seen in <5%.
A case series from Pakistan looking at 101 patients with a diagnosis of PD did not find major differences in age of onset of disease manifestations in comparison to similar samples from other countries. Two-thirds of patients were male; the mean age of disease onset was 56.4 years (ranged from 27–87); the mean duration of disease at the time of diagnosis was 5 years. 60% had disease onset during the 6th or 7th decade of life. Cognitive impairment was apparent after 10 years or longer of disease duration .
A study from Israel looked at 159 patients with PD that included Ashkenazi and Yemenite Jews. The age of onset was 10 years younger in the Yemenite Jew population. The tremor was the initial feature in just under half of the patients in both groups. 35% and 22% of the group had a positive family history of PD, respectively. The Yemenite group showed a higher prevalence of cognitive impairment and depression and also had a higher rate of disease progression . LRRK2 mutation was estimated to be 10.6% in sporadic cases of PD in Ashkenazi Jews in Israel and 26% of familial cases in study . Overall, the Yemenite Jews did not have the LRK mutation identified in Ashkenazi Jews, which may explain the difference in phenotype.
Also, The MDS gene database has data on only 3 of the autosomal recessive EOPD, and the data sources from the region mainly contain only case reports and information on selected cohorts and families with the conditions. Although these sources indirectly implicate autosomal recessive mutations, detecting the frequency or prevalence of these mutations which would require extensive genetic studies across the MENASA population. Besides, data from many of the countries are not available.
The consensus process indicated several areas that need to be addressed to improve the care of people with PD in the MENASA countries (Table 2). The task force members agreed that eight overarching principles should form the basis of the consensus statement: 1) the need for more movement disorders specialists, 2) multidisciplinary care, 3) the need for accurate epidemiologic data, 4) the need for educational programs, 5) availability of drugs, 6) availability of more advanced therapy, 7) health care resources and infrastructure, and 8) a heightened level of awareness among general population and health care professionals. Specific areas of consideration for each of these are outlined in Supplementary Table 1.
There have been attempts to identify barriers for providing evidence-based care and clinical services for people with PD in the MENASA countries . Within the context of existing literature, and through a series of conferences, we aimed to assess existing data and available care for PD patients in the MENASA countries. Based on that, the task force members agreed on eight priority areas to improve the status of PD care and other movement disorders in the region. The following is a discussion of these items.
The need for more movement disorder specialists and more educational opportunities in the field
In regards to the provision of care to PD patients, consensuses pointed to the shortage of specialized movement disorders’ clinics in the region and a very low number of movement disorder specialists. This conclusion is in line with data obtained from a previously conducted survey by our Task Force  and is also reflected by the low numbers of MDS members from the MENASA countries (Table 1). This is also consistent with the WHO Neurology atlas of country resources for neurological disorders that reported the lack of consultant neurologists in Africa , and similar reports by Khalifa et al.  in the Arab region.
The collective experience gathered from the task force consensus is that most patients in the region receive care at either general neurology or general medicine clinics. While basic care is available, more sophisticated treatments for advanced diseases, such as interventional therapies for advanced PD, are lacking. This limitation may affect patients’ quality of care. Movement disorders are usually complex conditions, and provision of care by neurologists with multidisciplinary support improves the delivery of standards of care and outcomes  . Indeed, in one study, care by a specialized neurologist was associated with higher adherence to quality care indicators, better education by the patient and caregiver regarding the disease, and greater access to advanced therapy .
The task force agreed that one solution is the regional promotion of training opportunities in movement disorders (Supplementary Table 1). An understanding of the medical education infrastructure and options available in each country will be needed to tailor education programs accordingly. Where possible, integration of movement disorders into medical school curricula may maximize the number of physicians receiving a minimum amount of training in movement disorders. Including movement disorders training for general physicians will also be essential . In countries where formal sub-specialty training is available establishing, promoting, and supporting fellowships in movement disorders will allow for additional advanced (sub-specialty) training. Facilitating access to high-quality educational courses and encouraging neurologists to participate should be liaised with health authorities and neurological societies in MENASA countries. Possible formats could include sponsored programs that would allow health care providers from MENASA countries to train in established movement disorders centers. Creating symposia and congresses aimed at providing updates in the field would be another means of improving education on movement disorders among MENASA healthcare providers. The provision of online courses may be particularly helpful in improving access to such educational opportunities. In countries where continuing medical education (CME) is necessary for the renewal of medical licenses, incentivizing physicians with CME opportunities may be useful. Toward this goal of advancing education and training in the field of movement disorders, there have been recent efforts to establish a center-to-center movement disorders training program through MDS . Additionally, a series of educational courses in the field of PD and movement disorders were coordinated in the region through the MDS ; some of these were online courses. These courses provided a platform to initiate a structured evidence-based educational process to deliver skills for better comprehensive care of PD in the region. Recently, MDS has formed the Middle East Working Group for PD and movement disorders to address these issues more thoroughly .
Improving access to multidisciplinary care was seen as the second most important issue. Given the complexity of PD, a multidisciplinary approach is likely needed to optimize the care of such patients. Indeed, such care models have been shown to improve quality of life in PD in randomized trials [61, 62]. As yet, several barriers to establishing multidisciplinary care in MENASA countries exist, such as lack of neurologists and ancillary health care providers trained in PD. Others include the paucity of centers providing the whole range of necessary services, and the need to re-organize them in the rare instances that they are available. Suggestions from the task force members on how these barriers can be addressed are provided in Supplementary Table 1.
The need for accurate epidemiologic data
The need for more accurate data was identified as a key priority by task force members. Epidemiological data are critical to identifying population needs, forming policies, and allocating research and health care resources. This, in turn, would inform healthcare provider training, and allow for systematic improvements in care and treatment gaps, including the availability of medications. Accurate population-level epidemiologic data are also essential for the study of the region or country-specific environmental and genetic risk factors. Although some information is available , most of the data on incidence and prevalence of PD and other movement disorders in the Middle East are old (Table 1), inconclusive and often conflicting . Genetic forms of PD may be disproportionately prevalent in the Middle East because of higher rates of consanguineous marriages in this part of the world . While 16% of the world’s PD population are estimated to reside in MENASA countries [65, 66], this may be an underestimate due to underreporting and under-diagnosis of the illness. This, in turn, may result from the existing limitations in health care surveillance infrastructure and delivery present in many MENASA countries. Gathering data on PD epidemiology will likely be achieved via a multi-layered approach. In countries where healthcare systems are nationalized, healthcare administrative databases may be a key source of epidemiologic data. In other countries, insurance claims and/or pharmaceutical utilization/prescribing practices may provide useful data on prevalence and even incidence. In some countries, partnering with local health organizations and other non-governmental organizations may provide key opportunities for fieldwork to understand PD prevalence. Where advanced care is provided in centralized tertiary care centers, establishing patient registries may be useful in gathering key information.
Availability of drugs and advanced therapies
The availability and affordability of treatment are also barriers for delivering care to PD patients, especially for advanced disease. Access to advanced PD therapies such as deep brain stimulation (DBS) continues to be limited even in developed countries such as the United States [67, 68], despite a high level of evidence of efficacy for such therapies. While the unit cost of some PD medications is relatively low in MENASA countries compared to costs in Western markets, the cost is high based on the cost of living and income ratio. This is compounded by the lack of availability of healthcare insurance to many (see further below), resulting in suboptimal care options for control of the disease . The most commonly prescribed drugs are L-Dopa preparations followed by dopamine agonists. However, access to therapies varies within countries across different regions in addition to challenges with substandard and falsified medical products becoming an increasing life-threatening concern . Access to levodopa, considered first-line therapy for PD, may be inconsistent. In a recent survey of public and private pharmacies in Nigeria, generic levodopa was found to be less available and more expensive than other agents such as dopamine agonists and anticholinergic medications . Based on the anecdotal report of task force members, lack of individual health insurance coverage makes the out-of-pocket cost to the patient highly burdensome, and limited access to advanced therapies results in poor control of the disease .
Overall, some advanced therapy is available at few centers in the Middle East . While the availability of neurosurgical stereotactic procedures and drug-infusion therapies were not available in many countries according to respondents, the practice of DBS is growing with some challenges, not only regarding its cost but also the lack of well-trained experts to manage it. This also applies to infusion therapies, which are less commonly available, even in specialized centers. This is likely in part due to the significant maintenance costs . As these advanced therapies become increasingly available, their healthcare providers must be proficient regarding candidacy for these therapies . Future work is needed to characterize the availability of drugs and which medications are prescribed/used, cost considerations, and access to advanced therapies in the MENASA region.
Health care resources and infrastructure
Private and public health insurance were available to cover the cost of healthcare according to nearly half of the survey responders. Even though we elected to study a group of countries based on geographical distribution and cultural similarities, we note heterogeneity between the countries of the MENA and SA regions. For instance, there is a discrepancy even within the Arab countries in terms of availability of funds for health care, with more of these funds being available in oil-rich Gulf countries of Saudi Arabia, Kuwait, Qatar, Bahrain, Oman, and United Arab Emirates. Historically, these countries have provided government-funded health care for their citizens. However, due to lack of expertise and skills, only very few centers offer advanced therapies for PD despite ample financial resources. Physical, occupational, and speech rehabilitation are an integral part of the care of PD patients. Provided as part of a multidisciplinary care system, this can substantially improve patient outcomes and quality of life . In MENASA countries there is a lack of rehabilitation centers specialized to offer care to patients with PD, which adds to the burden of the disease. Where a few centers exist to provide comprehensive care  and physical rehabilitation, several barriers reduce patient access to them .
Level of awareness among the general population and health care professionals
Increasing the level of awareness among the public as well as health care professionals was one of the priorities for the task force members. A lack of education about the disease among providers, patients, and their families, and the public may result in delayed diagnosis. Taskforce members report a paucity of educational materials available in the Arabic, Persian, Bangla, Urdu language and other languages commonly used in MENASA countries. Illiteracy, prevalent among some subgroups of MENASA countries, is also a major challenge to increasing awareness.
Lack of public awareness also makes it difficult for patients and their caregivers to live and actively engage in their communities. Anecdotal experience indicates that the effect of stigma from PD as a chronic illness is common in Jordan and MENASA. There is a lack of informational resources such as informational websites, societies, support groups, and brochures available in Arabic and other regional languages ; social stigma may delay or prevent patients from seeking medical care . Support groups and other patient/community resources have the potential to provide peer support and reduce stigma. However, to the knowledge of the authors, support groups for individuals with PD do not exist in the vast majority of the MENASA countries. As efforts emerge to improve support for patients in the community, considering specific cultural factors will be critical. Support group structures that are successful in North American and Western European cultures may not necessarily succeed in MENASA countries. Data on this are limited, and as a first step, pilot studies to determine patient attitudes towards PD support groups are needed.
To address this practical issue, the task force members started the translation of patient educational leaflets into various regional languages including Arabic, Persian, Bangla, and Urdu that are available on the MDS website. These contain significant information about PD, signs and symptoms and management. Members of the task force from different countries started to create their educational materials as well in different forms and designs to reach a wide sector of the target audience . Additionally, members from the task force have translated into Arabic highly utilized clinical rating scales, namely the MDS-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) and the MDS-Unified Dyskinesia Rating Scale (MDS-UDysRS). The process of validation and cultural adaptation to the Arabic versions of these scales is in progress with the prospect of serving future research and routine clinical practice. Efforts to generate auditory and visual educational materials on PD will be key to increasing awareness about PD among MENASA residents with low literacy.
Limitations of this work
Interpretation of the voting results must be done while accounting for the small number of task force members (n = 13). However, this limitation has been mitigated taking into account the existing literature and survey data while synthesizing the priorities. The triangulation with data reported from the literature as well as the consensus of the task force members adds to the credibility of the reported data. Overall, we would like to emphasize that data reported here is considered to be pilot data which merits further investigations.
We propose the following areas of development to enhance the care of patients with PD. These are general future directions and would need to be tailored for implementation in different countries to adapt to country-specific health-care system structures and resources.
1) Training providers to deliver high-quality PD care. This may be achieved by on-the-ground engagement with medical schools, residency programs, and ancillary health care provider education programs. This can be facilitated by international, regional, national and local neurological and movement disorders societies.
2) Improving access to care to healthcare providers trained in PD and other movement disorders. Telemedicine  may be used to reach patients that reside in areas that are far from specialist care. Encouraging the use of electronic medical record systems to monitor the delivery of health care would facilitate the delivery of care remotely.
3) Creating a network of movement disorders specialists in some MENASA countries and organizing an infrastructure to allow for systematic data collection. This could translate into further collaborations to help gather data on epidemiology, genetic contributors, and environmental risk factors .
4) In the long-term, establishing centers of excellence, modeled on those in North America, Europe, and other regions will maximize the delivery of optimal care to PD patients. These centers would lead the way to provide multidisciplinary care, such as medical, surgical, psychiatric/psychological care, rehabilitation services, and home care, as well as establishing social support groups to patients and families caring for patients with parkinsonism.
5) Creating networks for patients and caregivers in the region: to educate them more about the disease, provide further support, encourage more socialization, foster learning how to live with the disease, and strengthen the bond between them and their communities.
The authors confirm that the approval of an institutional review board and informed consent was not required for this work. Additionally, authors confirm that they have read the Journal’s position on issues involved in ethical publication and affirm that this work is consistent with those guidelines.
CONFLICT OF INTEREST
Professor Beomseok Jeon received funding support from Peptron, Ipsen Korea, Abbvie Korea. Dr. Junaid Siddiqui is a PI in an industry-sponsored trial. All other authors have no conflict of interest to report related to this work.
The authors would like to acknowledge Dr. Christopher G. Goetz for providing invaluable guidance throughout the process and for reviewing the manuscript. The authors would also like to thank Dr. Rizwan S. Bajwa for reviewing the manuscript. Authors also would like to thank International Parkinson and Movement Disorders Society for their support and in particular Ms. Sharon Baudry and Stephanie Jensen for the administrative support to this work.
 The supplementary material is available in the electronic version of this article: http://dx.doi.org/10.3233/JPD-191751.
De Lau LM , Breteler MM ((2006) ) Epidemiology of Parkinson’s disease. Lancet Neurol 5: , 525–535.
Abubakar I , Tillmann T , Banerjee A ((2015) ) Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: A systematic analysis for the Global Burden of Disease Study 2013. Lancet 385: , 117–171.
Benamer HT , de Silva R , Siddiqui KA , Grosset DG ((2008) ) Parkinson’s disease in Arabs: A systematic review. Mov Disord 23: , 1205–1210.
Lim S-Y , Tan AH , Ahmad-Annuar A , Klein C , Tan LC , Rosales RL , Bhidayasiri R , Wu Y-R , Shang H-F , Evans AH ((2019) ) Parkinson’s disease in the Western Pacific Region. Lancet Neurol 18: , 865–879.
((2018) ) Global, regional, and national burden of Parkinson’s disease, 1990–2016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol 17: , 939–953.
Dorsey ER , Elbaz A , Nichols E , Abd-Allah F , Abdelalim A , Adsuar JC , Ansha MG , Brayne C , Choi J-YJ , Collado-Mateo D ((2018) ) Global, regional, and national burden of Parkinson’s disease, 1990–2016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol 17: , 939–953.
KhalilH, ChahineL, SiddiquiJ, AldaajaniZ, BajwaJA ((2020) ) Parkinson’s disease in theMENASAcountries. The Lancet Neurology in press.
Lukonga MI ((2018) ) Fintech, Inclusive Growth and Cyber Risks: Focus on the MENAP and CCA Regions, International Monetary Fund.
Rieckmann P , Boyko A , Centonze D , Coles A , Elovaara I , Havrdova E , Hommes O , Lelorier J , Morrow SA , Oreja-Guevara C , Rijke N , Schippling S ((2013) ) Future MS care: A consensus statement of the MS in the 21st Century Steering Group. J Neurol 260: , 462–469.
Middle East Working Group MDS/Asian and Oceanian Section/Middle East Working Group, https://www.movementdisorders.org/MDS-AOS/Middle-East-Working-Group.htm
Khalil H , Aldaajani Z , Abualmelh M , Mohammad T , Salari M , Bhatt M , Tabbal S , Syed NA , Jeon B , Goetz C ((2017) ) The management of Parkinson’s disease in the Middle East countries: The MDS-middle east task force survey. Mov Disord 32: (Suppl 2), Abstract number 1296. https://www.mdsabstracts.org/abstract/the-management-of-parkinsons-disease-in-the-middle-east-countries-the-mds-middle-east-task-force-survey/.
United Nations Population Division, https://esa.un.org/unpd/wpp/, Accessed March 22, 2018.
Tan LCS ((2013) ) Epidemiology of Parkinson’s disease. Neurol Asia 18: , 231–238.
El Tallawy HN , Farghaly WM , Rageh TA , Shehata GA , Metwaly NA , Elftoh NA , Hegazy AM , El Moselhy EA , Rayan I , Al Fawal BM ((2010) ) Epidemiology of major neurological disorders project in Al Kharga district, New Valley, Egypt. Neuroepidemiology 35: , 291–297.
El Tallawy HN , Farghaly WM , Rageh TA , Shehata GA , Badry R , Metwally NA , El Moselhy EA , Hassan M , Sayed MA , Waris AA ((2013) ) Door-to-door survey of major neurological disorders (project) in Al Quseir City, Red Sea Governorate, Egypt. Neuropsychiatr Dis Treat 9: , 767–771.
Gourie-Devi M ((2014) ) Epidemiology of neurological disorders in India: Review of background, prevalence and incidence of epilepsy, stroke, Parkinson’s disease and tremors. Neurol India 62: , 588–598.
Bharucha NE , Bharucha EP , Bharucha AE , Bhise AV , Schoenberg BS ((1988) ) Prevalence of Parkinson’s disease in the Parsi community of Bombay, India. Arch Neurol 45: , 1321–1323.
Khan S , Nabi G , Naeem M , Ali L , Silburn PA , Mellick GD ((2016) ) A door-to-door survey to estimate the prevalence of Parkinsonism in Pakistan. Neuropsychiatr Dis Treat 12: , 1499–1506.
Salari M , Mirmosayyeb O , Etemadifar M , Shaygannejad V , Khorvash F , Najafi MR , Ashtari F , Chitsaz A ((2018) ) Demographic features and clinical characteristics of patients with Parkinson’s disease in Isfahan, Iran. Iran J Neurol 17: , 6–10.
Willis AW , Evanoff BA , Lian M , Criswell SR , Racette BA ((2010) ) Geographic and ethnic variation in Parkinson disease: A population-based study of US Medicare beneficiaries. Neuroepidemiology 34: , 143–151.
Van Der Mark M , Brouwer M , Kromhout H , Nijssen P , Huss A , Vermeulen R ((2011) ) Is pesticide use related to Parkinson disease? Some clues to heterogeneity in study results. Environ Health Perspect 120: , 340–347.
Priyadarshi A , Khuder SA , Schaub EA , Priyadarshi SS ((2001) ) Environmental risk factors and Parkinson’s disease: A meta analysis. Environ Res 86: , 122–127.
Perry DC , Sturm VE , Peterson MJ , Pieper CF , Bullock T , Boeve BF , Miller BL , Guskiewicz KM , Berger MS , Kramer JH ((2016) ) Association of traumatic brain injury with subsequent neurological and psychiatric disease: A meta-analysis. J Neurosurg 124: , 511–526.
Liu R , Guo X , Park Y , Huang X , Sinha R , Freedman ND , Hollenbeck AR , Blair A , Chen H ((2012) ) Caffeine intake, smoking, and risk of Parkinson disease in men and women. Am J Epidemiol 175: , 1200–1207.
Kenborg L , Lassen CF , Ritz B , Andersen KK , Christensen J , Schernhammer ES , Hansen J , Wermuth L , Rod NH , Olsen JH ((2015) ) Lifestyle, family history, and risk of idiopathic Parkinson disease: A large Danish case-control study. Am J Epidemiol 181: , 808–816.
Khedr EM , Al Attar GS , Kandil MR , Kamel NF , Abo Elfetoh N , Ahmed MA ((2012) ) Epidemiological study and clinical profile of Parkinson’s disease in the Assiut Governorate, Egypt: A community-based study. Neuroepidemiology 38: , 154–163.
Mereu G , Pacitti C , Argiolas A ((1983) ) Effect of (-)-cathinone, a khat leaf constituent, on dopaminergic firing and dopamine metabolism in the rat brain. Life Sci 32: , 1383–1389.
Khedr EM , Fawi G , Abbas MAA , Mohammed TA , El-Fetoh NA , Attar GA , Zaki AF ((2015) ) Prevalence of Parkinsonism and Parkinson’s disease in Qena governorate/Egypt: A cross-sectional community-based survey. Neurol Res 37: , 607–618.
Gupta V , Garg RK , Pant KK , Khattri S ((2014) ) A study on risk factors for Parkinson’s disease in Indian population. Bioinformation 10: , 342.
Sanyal J , Chakraborty D , Sarkar B , Banerjee TK , Mukherjee SC , Ray BC , Rao V ((2010) ) Environmental and familial risk factors of Parkinsons disease: Case-control study. Can J Neurol Sci 37: , 637–642.
Fitzmaurice AG , Rhodes SL , Cockburn M , Ritz B , Bronstein JM ((2014) ) Aldehyde dehydrogenase variation enhances effect of pesticides associated with Parkinson disease. Neurology 82: , 419–426.
Chuang Y-H , Lill CM , Lee P-C , Hansen J , Lassen CF , Bertram L , Greene N , Sinsheimer JS , Ritz B ((2016) ) Gene-environment interaction in Parkinson’s disease: Coffee, ADORA2A, and CYP1A2. Neuroepidemiology 47: , 192–200.
Yang F , Pedersen NL , Ye W , Liu Z , Norberg M , Forsgren L , Trolle Lagerros Y , Bellocco R , Alfredsson L , Knutsson A ((2016) ) Moist smokeless tobacco (Snus) use and risk of Parkinson’s disease. Int J Epidemiol 46: , 872–880.
Ozelius LJ , Senthil G , Saunders-Pullman R , Ohmann E , Deligtisch A , Tagliati M , Hunt AL , Klein C , Henick B , Hailpern SM ((2006) ) LRRK2 G2019S as a cause of Parkinson’s disease in Ashkenazi Jews. N Engl J Med 354: , 424–425.
Lesage S , Ibanez P , Lohmann E , Pollak P , Tison F , Tazir M , Leutenegger AL , Guimaraes J , Bonnet AM , Agid Y ((2005) ) G2019S LRRK2 mutation in French and North African families with Parkinson’s disease. Ann Neurol 58: , 784–787.
Hashad DI , Abou-Zeid AA , Achmawy GA , Allah HMS , Saad MA ((2011) ) G2019S mutation of the leucine-rich repeat kinase 2 gene in a cohort of Egyptian patients with Parkinson’s disease. Genet Test Mol Biomarkers 15: , 861–866.
El Haj RB , Salmi A , Regragui W , Moussa A , Bouslam N , Tibar H , Benomar A , Yahyaoui M , Bouhouche A ((2017) ) Evidence for prehistoric origins of the G2019S mutation in the North African Berber population. PLoS One 12: , e0181335.
Al-Mubarak BR , Bohlega SA , Alkhairallah TS , Magrashi AI , AlTurki MI , Khalil DS , AlAbdulaziz BS , Abou Al-Shaar H , Mustafa AE , Alyemni EA , Alsaffar BA , Tahir AI , Al Tassan NA ((2015) ) Parkinson’s disease in Saudi patients: A genetic study. PLoS One 10: , e0135950.
Need AC , Goldstein DB ((2009) ) Next generation disparities in human genomics: Concerns and remedies. Trends Genet 25: , 489–494.
Tadmouri GO , Nair P , Obeid T , Al Ali MT , Al Khaja N , Hamamy HA ((2009) ) Consanguinity and reproductive health among Arabs. Reprod Health 6: , 17.
Tadmouri GO , Sastry KS , Chouchane L ((2015) ) Arab gene geography: From population diversities to personalized medical genomics. Glob Cardiol Sci Pract 2015: , 54.
Al-Din ASN , Al-Kurdi A , Dasouki M , Wriekat A-L , Al-Khateeb M , Mubaidin A , Al-Hiari M ((1994) ) Autosomal recessive ataxia, slow eye movements and psychomotor retardation. J Neurol Sci 124: , 61–66.
Williams DR , Hadeed A , al-Din ASN , Wreikat AL , Lees AJ ((2005) ) Kufor Rakeb disease: Autosomal recessive, levodopa-responsive parkinsonism with pyramidal degeneration, supranuclear gaze palsy, and dementia. Mov Disord 20: , 1264–1271.
Ramirez A , Heimbach A , Gründemann J , Stiller B , Hampshire D , Cid LP , Goebel I , Mubaidin AF , Wriekat A-L , Roeper J ((2006) ) Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase. Nat Genet 38: , 1184–1191.
Leutenegger A-L , Salih MA , Ibáñez P , Mukhtar MM , Lesage S , Arabi A , Lohmann E , Dürr A , Ahmed AE , Brice A ((2006) ) Juvenile-onset Parkinsonism as a result of the first mutation in the adenosine triphosphate orientation domain of PINK1. Arch Neurol 63: , 1257–1261.
Olgiati S , Quadri M , Fang M , Rood JP , Saute JA , Chien HF , Bouwkamp CG , Graafland J , Minneboo M , Breedveld GJ , Zhang J ; International Parkinsonism Genetics Network, Verheijen FW , Boon AJ , Kievit AJ , Jardim LB , Mandemakers W , Barbosa ER , Rieder CR , Leenders KL , Wang J , Bonifati V ((2016) ) DNAJC6 mutations associated with early-onset Parkinson’s disease. Ann Neurol 79: , 244–256.
Gouider-Khouja N , Belal S , Hamida MB , Hentati F ((2000) ) Clinical and genetic study of familial Parkinson’s disease in Tunisia. Neurology 54: , 1603–1609.
Peeraully T , Tan E ((2012) ) Genetic variants in sporadic Parkinson’s disease: East vs West. Parkinsonism Relat Disord 18: , S63–S65.
Khealani B , Baig S ((2006) ) Clinical spectrum of Parkinson’s disease from Pakistan. Singapore Med J 47: , 1075–1079.
Djaldetti R , Hassin-Baer S , Farrer M , Vilariño-Güell C , Ross OA , Kolianov V , Yust-Katz S , Treves T , Barhum Y , Hulihan M ((2008) ) Clinical characteristics of Parkinson’s disease among Jewish Ethnic groups in Israel. J Neural Transm (Vienna) 115: , 1279–1284.
Alcalay RN , Mirelman A , Saunders-Pullman R , Tang M-X , Mejia Santana H , Raymond D , Roos E , Orbe-Reilly M , Gurevich T , Bar Shira A , Gana Weisz M , Yasinovsky K , Zalis M , Thaler A , Deik A , Barrett MJ , Cabassa J , Groves M , Hunt AL , Lubarr N , San Luciano M , Miravite J , Palmese C , Sachdev R , Sarva H , Severt L , Shanker V , Swan MC , Soto-Valencia J , Johannes B , Ortega R , Fahn S , Cote L , Waters C , Mazzoni P , Ford B , Louis E , Levy O , Rosado L , Ruiz D , Dorovski T , Pauciulo M , Nichols W , Orr-Urtreger A , Ozelius L , Clark L , Giladi N , Bressman S , Marder KS ((2013) ) Parkinson disease phenotype in Ashkenazi Jews with and without LRRK2 G2019S mutations. Mov Disord 28: , 1966–1971.
Siddiqui JH , Bhatti D , Alsubaie F , Bajwa JA ((2018) ) Movement disorders and deep brain stimulation in the Middle East. World Neurosurg 113: , e314–e319.
World Health Organization ((2006) ) Neurological disorders: Public health challenges, World Health Organization.
Khalifa A , Aarli JA ((2011) ) Global perspectives. Neurology 77: , 1565–1567.
Willis AW , Schootman M , Tran R , Kung N , Evanoff BA , Perlmutter JS , Racette BA ((2012) ) Neurologist-associated reduction in PD-related hospitalizations and health care expenditures. Neurology 79: , 1774–1780.
Lim S-Y , Tan AH , Fox SH , Evans AH , Low SC ((2017) ) Integrating patient concerns into Parkinson’s disease management. Curr Neurol Neurosci Rep 17: , 3.
Racette BA , Willis AW ((2015) ) Time to change the blind men and the elephant approach to Parkinson disease? Neurology 85: , 190–196.
Zinchuk AV , Flanagan EP , Tubridy NJ , Miller WA , McCullough LD ((2010) ) Attitudes of US medical trainees towards neurology education: “Neurophobia” - a global issue. BMC Med Educ 10: , 49.
Center to Center Movement Disorders Training Program, https://www.movementdisorders.org/MDS/Education/Center-to-Center-Movement-Disorders-Training-Program.htm
Bajwa J , Khalil H ((2015) ) First Middle East camp for Parkinson’s disease, Movement Disorders and neuromodulation: Review of outcomes and implications for future directions: 960. Mov Disord 30: , S372.
Ferrazzoli D , Ortelli P , Zivi I , Cian V , Urso E , Ghilardi MF , Maestri R , Frazzitta G ((2018) ) Efficacy of intensive multidisciplinary rehabilitation in Parkinson’s disease: A randomised controlled study. J Neurol Neurosurg Psychiatry 89: , 828–835.
van der Marck MA , Kalf J , Sturkenboom IH , Nijkrake MJ , Munneke M , Bloem BR ((2009) ) Multidisciplinary care for patients with Parkinson’s disease. Parkinsonism Relat Disord 15: , S219–S223.
Alamri Y , MacAskill M , Anderson T , Benamer H ((2015) ) Parkinson’s disease in the Gulf countries: An updated review. Eur Neurol 74: , 222–225.
Al Adawi S ((2008) ) Caring for Arab patients: A biopsychosocial approach. Sultan Qaboos Univ Med J 8: , 233.
World Health Organization ((2008) ), The Global Burden of Disease: World Health Organization..
GBD 2016 Parkinson’s Disease Collaborators ((2018) ) Global, regional, and national burden of Parkinson’s disease, 1990–2016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol 17: , 939–953.
Willis AW , Schootman M , Kung N , Wang X-Y , Perlmutter JS , Racette BA ((2014) ) Disparities in deep brain stimulation surgery among insured elders with Parkinson disease. Neurology 82: , 163–171.
Chan AK , McGovern RA , Brown LT , Sheehy JP , Zacharia BE , Mikell CB , Bruce SS , Ford B , McKhann GM ((2014) ) Disparities in access to deep brain stimulation surgery for Parkinson disease: Interaction between African American race and Medicaid use. JAMA Neurol 71: , 291–299.
Mokaya J , Dotchin CL , Gray WK , Hooker J , Walker RW ((2016) ) The accessibility of Parkinson’s disease medication in Kenya: Results of a national survey. Mov Disord Clin Pract 3: , 376–381.
Newton PN , Bond KC ((2019) ) Global access to quality-assured medical products: The Oxford Statement and call to action. Lancet Global Health 7: , e1609–e1611.
Okubadejo NU , Ojo OO , Wahab KW , Abubakar SA , Obiabo OY , Salawu FK , Nwazor EO , Agabi OP , Oshinaike OO ((2019) ) A nationwide survey of Parkinson’s disease medicines availability and affordability in Nigeria. Mov Disord Clin Pract 6: , 27–33.
Wang G , Cheng Q , Zheng R , Tan YY , Sun XK , Zhou HY , Ye XL , Wang Y , Wang Z , Sun BM ((2006) ) Economic burden of Parkinson’s disease in a developing country: A retrospective cost analysis in Shanghai, China. Mov Disord 21: , 1439–1443.
Siddiqui JH , Aldaajani Z , Mehanna R , Changizi BK , Bhatti D , Al-Johani ZG , Shukla AW , Fernandez HH , Bajwa JA ((2018) ) Rationale and patient selection for interventional therapies in Parkinson’s disease. Expert Rev Neurother 18: , 811–823.
van der Eijk M , Nijhuis FA , Faber MJ , Bloem BR ((2013) ) Moving from physician-centered care towards patient-centered care for Parkinson’s disease patients. Parkinsonism Relat Disord 19: , 923–927.
AlSwaiti FY , Mayo R , Bajwa JA ((2015) ) The Parkinson’s disease and movement disorders program at King Fahad Medical City. Perspect Global Issues Commun Sci Relat Disord 5: , 33–40.
Khalil H , Bajwa JA ((2015) ) Barriers and facilitators in physical rehabilitation for Parkinson’s disease in the Arabian World. Mov Disord Clin Pract 2: , 227–229.
Khalil H , Nazzal M , Al-Sheyab N ((2016) ) Parkinson’s disease in Jordan: Barriers and motivators to exercise. Physiother Theory Pract 32: , 509–519.
Kaddumukasa M , Kakooza A , Kaddumukasa MN , Ddumba E , Sajatovic M , Katabira E ((2015) ) Knowledge and attitudes of Parkinson’s disease in rural and urban Mukono District, Uganda: A cross-sectional, community-based study. Parkinsons Dis 2015: , 196150.
El-Jaafary S , Amer H , Fouad A , Tawfiq B , El Sabbahy L , Bayoumy A , Abulkarim B , Gamal B , Nafea H , Shehata H ((2018) ) Future doctors as health educators: Undergraduate medical students raise awareness and unite for Parkinson’s disease. Mov Disord 33: , S42–S43.
Hassan A , Dorsey ER , Goetz CG , Bloem BR , Guttman M , Tanner CM , Mari Z , Pantelyat A , Galifianakis NB , Bajwa JA , Gatto EM , Cubo E ((2018) ) Telemedicine use for movement disorders: A global survey. Telemed J E Health 24: , 979–992.
Zabetian CP , Mata IF , Latin American Research Consortium on the Genetics of PD (LARGE-PD) ((2017) ) LARGE-PD: Examining the genetics of Parkinson’s disease in Latin America. Mov Disord 32: , 1330–1331.
Benamer HT ((2014) ) Neurological Disorders in the Arab World, Springer.
Benamer HT ((2010) ) Neurology expertise and postgraduate training programmes in the Arab world: A survey. Eur Neurol 64: , 313–318.
Bergen DC , World Federation of Neurology Task Force on Neurological Services ((2002) ) Training and distribution of neurologists worldwide. J Neurol Sci 198: , 3–7.
Steck A , Struhal W , Sergay SM , Grisold W , Education Committee World Federation of Neurology ((2013) ) The global perspective on neurology training: The World Federation of Neurology survey. J Neurol Sci 334: , 30–47.
Mansouri B , Ahsan B ((2006) ) Neurology in Iran. Iran J Neurol 5: , 19–23.
Anca M , Paleacu D , Shabtai H , Giladi N ((2002) ) Cross-sectional study of the prevalence of Parkinson’s disease in the Kibbutz movement in Israel. Neuroepidemiology 21: , 50–55.
Bower JH , Zenebe G ((2005) ) Neurologic services in the nations of Africa. Neurology 64: , 412–415.
Masalha R , Kordysh E , Alpert G , Hallak M , Morad M , Mahajnah M , Farkas P , Herishanu Y ((2010) ) The prevalence of Parkinson’s disease in an Arab population, Wadi Ara, Israel. Isr Med Assoc J 12: , 32–35.
Romdhane NA , Hamida MB , Mrabet A , Larnaout A , Samoud S , Hamda AB , Hamda MB , Oueslati S ((1993) ) Prevalence study of neurologic disorders in Kelibia (Tunisia). Neuroepidemiology 12: , 285–299.
Saleh MABQ , Makki AM ((2008) ) Mental health in Yemen: Obstacles and challenges. Int Psychiatry 5: , 90–92.
Roxas A Jr. , Mehndiratta MM , Bornstein N , Macdonell R , Lim KS , Ng PW , Dashzeveg S , Mizusawa H , Esmatullah H , Wu SL , Chen C , Kurniawan M , Rha JH , Wasay M , Poungvarin N , Gunatilake S , Thang NH ((2017) ) The professional practice and training of neurology in the Asian and Oceanian Region: A cross-sectional survey by the Asian and Oceanian Association of Neurology (AOAN). J Neurol Sci 382: , 108–115.
Chowdhury RN , Hasan AH , Rahman YU , Khan SI , Hussain AR , Ahsan S ((2014) ) Pattern of neurological disease seen among patients admitted in tertiary care hospital. BMC Res Notes 7: , 202.
McKenzie ED , Nirola DK , Deki S , Tshering L , Patenaude B , Clark SJ , Cash SS , Thibert R , Zepeda R , Leung EC ((2016) ) Medication prescribing and patient-reported outcome measures in people with epilepsy in Bhutan. Epilepsy Behav 59: , 122–127.
Khadilkar S ((2013) ) Neurology in India. Ann Indian Acad Neurol 16: , 465.
Gourie-Devi M , Gururaj G , Satishchandra P , Subbakrishna D ((2004) ) Prevalence of neurological disorders in Bangalore, India: A community-based study with a comparison between urban and rural areas. Neuroepidemiology 23: , 261–268.
Rajbhandari KC ((2004) ) Epilepsy in Nepal. Can J Neurol Sci 31: , 257–260.