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Dopaminergic Effect on Non-Motor Symptoms in Late Stage Parkinson’s Disease

[Journal of Parkinson’s Disease 8(3), 2018, 409–420. DOI 10.3233/JPD-181380]

https://content.iospress.com/articles/journal-of-parkinsons-disease/jpd181380

A typo was discovered in Table 3 (on page 415), line ‘D6: Gastrointestinal’, column ‘NMSS Score in “On” state’:

Published and wrong numbers: 12.0 (4.0-20.0). Correct numbers: 6.0 (2.7-12.0).

Below find the corrected version of Table 3:

Table 3

Non-Motor Symptoms in “off” and “on” states during L-dopa test as assessed with the modified NMSS (N = 30)

NMSS, item, domain“Off” state“On” stateDifference *
Number of pts with symptom present, n (%)NMSS score (median, q1–q3)Number of pts with symptom present, n (%)NMSS score (median, q1–q3) P-ValueNumber of pts with NMSSOff  >  NMSSOn, n (%)
1. Light headedness14 (47%)0.0 (0.0–4.5)12 (40%)0.0 (0.0–4.0)0.5164 (13%)
D1: Cardiovascular14 (47%)0.0 (0.0–4.5)12 (40%)0.0 (0.0–4.0)0.5164 (13%)
  3. Daytime sleepiness19 (63%)3.0 (0.0–6.0)19 (63%)3.0 (0.0–6.0)0.1255 (17%)
  4. Fatigue22 (73%)3.5 (0.0–8.0)20 (67%)2.5 (0.0–6.5) 0.017 11 (37%)
  5. Difficulty falling asleep9 (30%)0.0 (0.0–3.3)8 (27%)0.0 (0.0–2.3)0.1254 (13%)
  6. Restless legs16 (53%)1.0 (0.0–4.5)14 (47%)0.5 (0.0–4.0)0.4065 (17%)
D2: Sleep/fatigue30 (100%)10.0 (6.0–18.3)28 (93%)8.0 (5.5–14.0) 0.003 15 (59%)
  7. Lost interest in surrounding15 (50%)0.5 (0.0–6.0)14 (47%)0.0 (0.0–4.0)0.0867 (23%)
  8. Lack motivation20 (67%)3.5 (0.0–9.0)20 (67%)2.5 (0.0–8.0)0.1486 (20%)
  9. Feel nervous11 (37%)0.0 (0.0–4.5)9 (30%)0.0 (0.0–4.0) 0.008 8 (27%)
  10. Seem sad19 (63%)2.0 (0.0–6.0)16 (53%)2.0 (0.0–4.5) 0.037 9 (30%)
  11. Flat moods24 (80%)4.0 (1.0–6.0)19 (63%)3.0 (0.0–4.0) 0.003 15 (50%)
  12. Difficulty experiencing pleasure15 (50%)0.5 (0.0–4.5)13 (43%)0.0 (0.0–4.0) 0.007 10 (33%)
D3: Mood/apathy27 (90%)14.0 (6.0–38.3)25 (83%)13.0 (4.0–26.3) <0.001 21 (70%)
  16. Concentration20 (67%)2.0 (0.0–6.0)16 (53%)1.0 (0.0–4.0) 0.006 9 (30%)
  17. Forget things or events21 (70%)3.0 (0.0–6.0)22 (73%)2.0 (0.0–4.0)0.07810 (33%)
  18. Forget to do things19 (63%)2.5 (0.0–6.0)16 (53%)1.0 (0.0–4.5)0.2328 (27%)
D5: Attention/memory28 (93%)10.0 (2.0–16.5)28 (93%)6.0 (2.0–11.0) 0.006 15 (50%)
  19. Saliva23 (77%)4.0 (1.5–9.0)22 (73%)4.0 (0.0–9.0)0.3596 (20%)
  20. Swallowing14 (47%)0.0 (0.0–6.0)14 (47%)0.0 (0.0–4.0) 0.031 6 (20%)
D6: Gastrointestinal28 (93%)8.0 (4.0–12.0)27 (90%)6.0 (2.7–12.0) 0.009 12 (40%)
  22. Urgency22 (73%)5.0 (0.0–12.0)19 (63%)4.0 (0.0–12.0) 0.031 6 (20%)
  23. Frequency18 (60%)4.0 (0.0–12.0)17 (57%)3.0 (0.0–12.0)0.5005 (17%)
  24. Nocturia24 (80%)8.0 (2.0–12.0)24 (80%)5.0 (1.8–12.0)0.0635 (17%)
D7: Urinary27 (90%)15.0 (4.0–33.8)26 (87%)13.0 (4.0–29.3) 0.004 9 (30%)
  25. Interest in sex6 (20%)0.0 (0–0.0)6 (20%)0.0 (0.0–0.0)1.0000 (0%)
  26. Problems having sex15 (50%)4.0 (0.0–12.0)15 (50%)4.0 (0.0–12.0)1.0000 (0%)
D8: Sexual dysfunction16 (53%)10.0 (0.0–12.0)16 (53%)10.0 (0.0–12.0)1.0000 (0%)
  27. Pain15 (50%)0.5 (0.0–8.0)15 (50%)0.5 (0.0–6.5)0.7664 (13%)
  30. Excessive sweating8 (27%)0.0 (0.0–1.0)5 (17%)0.0 (0.0–0.0)0.1885 (17%)
D9: Miscellaneous19 (63%)3.0 (0.0–8.0)18 (60%)2.5 (0.0–7.3)0.5595 (17%)
NMSS total score30 (100%)79.0 (47.8–115.3)30 (100%)63.5 (44.8–96.3) <0.001 21 (70%)

NMSS, Non-Motor Symptoms Scale (modified; 0–276, higher = worse); q1–q3, first and third quartiles; D, domain; Pts, patients. Symptom present = score≥1 on each item/domain. NMSS score = severity×frequency.  *Differences between defined “off” and “on” states; number of patients who reported worse symptoms in the “off” than in the “on” state. P-values are from Wilcoxon sign-rank test for the comparisons of NMSS score between the defined “off” and “on” states. P-values were not adjusted for multiple testing. Bold P-values are statistically significant at P <  0.05.