Affiliations: [a] Department of Neuropsychiatry, Assiut University Hospital, Assiut, Egypt
| [b] Department of Neuropsychiatry, Aswan University Hospital, Aswan, Egypt
| [c] Department of Neuropsychiatry, Ain Shams University Hospital, Cairo, Egypt
| [d] Sobell Department of Motor Neuroscience and Movement Disorders, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
Correspondence to: Prof. Dr. Eman M. Khedr, Department of Neuropsychiatry, Faculty of Medicine, Assiut University Hospital, Assiut, Egypt. Tel.: +02 01005850632; Fax: +02 088 2333327; E-mail: [email protected].
Abstract: Background:There is evidence that both high and low frequency rTMS may have therapeutic effects on motor performance of Parkinson’s disease. Objective:The aim of the study was to conduct the first direct comparison of the two approaches. Methods:52 PD patients were randomly classified into two groups. The first group received 20 Hz and the 2nd group received 1 Hz rTMS with a total of 2000 pulses over M1of each hemisphere for ten days. Effects were assessed with the Unified Parkinson’s Disease Rating Scale part III (UPDRS), Instrumental Activity of Daily Living (IADL), and a self-assessment score (SA) before, after the last session, and one month later. Cortical excitability was measured before and after the end of sessions. Results:There was a significant improvement on all rating scales after either 1 Hz or 20 Hz rTMS, but the effect persisted for longer after 20 Hz (treatment X time interaction for UPDRS and IADL (P = 0.075 and 0.04, respectively). Neither treatment affected motor thresholds, but 20 Hz rTMS increased MEP amplitude and the duration of transcallosal inhibition. In an exploratory analysis, each group was subdivided into akinetic-rigid and tremor dominant subgroups and the effects of 1 Hz and 20 Hz treatment recalculated. There was weak evidence that patients with an akinetic-rigid presentation may respond better than those with predominant tremor. Conclusion:Both 20 Hz and 1 Hz rTMS improve motor function in PD, but 20 Hz rTMS is more effective.