Affiliations: [a] Department of Neurology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA
| [b] Department of Neuroscience, Washington University in St. Louis School of Medicine, St. Louis, MO, USA
| [c] Program in Physical Therapy, Washington University in St. Louis School of Medicine, St. Louis, MO, USA
| [d] Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, USA
| [e] Department of Radiology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA
Correspondence to: Meghan C. Campbell, Ph.D. Campus Box 8225, 4525 Scott Avenue, St. Louis, MO 63110-1093, USA. Tel.: +1 314 362 8222; Fax: +1 314 362 0168; E-mail: [email protected].
Abstract: Background: Freezing of gait (FOG) affects approximately 50% of people with Parkinson Disease (PD), impacting quality of life and placing financial and emotional strain on the individual and caregivers. People with PD and FOG have similar deficits in motor adaptation and cognition as individuals with cerebellar lesions, indicating the cerebellum may play a role in FOG. Objective: To examine potential differences in cerebellar volumes and their relationships with cognition between PD with (FOG+) and without FOG (FOG-). Methods: Sixty-three participants were divided into two groups, FOG+ (n = 25) and FOG- (n = 38), based on the New Freezing of Gait Questionnaire. Cognitive assessment included Trail Making, Stroop, Verbal Fluency, and Go-NoGo executive function tasks. All participants completed structural T1- and T2-weighted MRI scans. Imaging data were processed with FreeSurfer and the Spatially Unbiased Infratentorial toolbox to segment the cerebellum into individual lobules. Results: FOG+ performed significantly worse on phonemic verbal fluency (F(1, 22) = 7.06, p = 0.01) as well as the Go-NoGo task (F(1, 22) = 9.00, p = 0.004). We found no differences in cerebellar volumes between groups (F(4, 55) = 1.42, p = 0.24), but there were significant relationships between verbal fluency measures and lobule volumes in FOG-. Conclusions: These findings underscore the need for longitudinal studies to better characterize potential changes in cerebellar volume, cognitive function, and functional connectivity between people with PD with and without FOG.