Affiliations: [a] Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada
| [b] Department of Brain and Neurosciences, Division of Neurology, Faculty of Medicine, Tottori University, Japan
Centre d’Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Coeur de Montréal, Montréal, QC, Canada
| [d] Department of Psychology, Université du Québec à Montréal, Montreal, QC, Canada
Correspondence to: Dr. Ronald B. Postuma, Department of Neurology, L7-305 Montreal General Hospital, 1650 Cedar Avenue, Montreal, Quebec, H3G1A4, Canada. Tel.: +1 514 934 8026; Fax: +1 514 934 8265; E-mail: firstname.lastname@example.org.
Abstract: In a prospective study, we recently discovered 8 clinical predictors of dementia in Parkinson’s disease. Here, we validate these dementia predictors using two additional prospective cohorts (n = 134). After a 3.6-year follow-up, 35/134 developed dementia (7.2% per year). When confirming individual variables, 5/8 were significantly associated with dementia in the validation cohort. These included age, male sex, baseline RBD, orthostatic hypotension, and MCI. Bilateral onset, hallucinations and falls/freezing did not significantly predict dementia; however, point estimates of OR were all >1. In all cohorts, the strongest determinant for dementia development was the co-existence of RBD, MCI and orthostatic hypotension at baseline.
Keywords: Dementia, prediction, REM sleep behavior disorder, mild cognitive