Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Sorrentino, Pierpaoloa; b | Barbato, Antonioc | Del Gaudio, Luigia | Rucco, Rosariad; e | Varriale, Pasqualed; e | Sibilio, Michelinaf | Strazzullo, Pasqualec | Sorrentino, Giusepped; e; * | Agosti, Valeriad; e
Affiliations: [a] Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Italy | [b] Department of Clinical Neurophysiology, VUmc, Amsterdam, Nederlands | [c] Department of Clinical Medicine, University of Naples Federico II, Italy | [d] Department of Motor Sciences and Wellness, University of Naples Parthenope, Italy | [e] Institute Hermitage-Capodimonte, Naples, Italy | [f] Division of Pediatrics, Moscati Hospital, Aversa (CE), Italy
Correspondence: [*] Correspondence to: Prof. Giuseppe Sorrentino Via Medina 40, 80133, Naples, Italy. Tel.: +39 0815474771; +39 0817483501; Mobile: +39 3358421157; E-mail: [email protected].
Abstract: Type 1 Gaucher’s disease (GD1) is traditionally regarded as “non-neurological”. Spatiotemporal and kinematic analysis of gait was carried on thirteen GD1 patients and thirteen healthy controls. We identified a previously unknown subclinical reduction of amplitude of movements in GD1. Articular excursion of ankle, knee and hip was reduced during the swing phase of gait (p < 0.0001). Furthermore, the excursion of the knee appeared also significantly more asymmetric in GD1 patients (p = 0.02). Correction for age, BMI and basal walking speed did not modify the significance. Accordingly to the recent observations that GD1 predisposes to Parkinson’s disease, the impaired and asymmetric gait kinematics that we observed might be interpreted as a form of extrapyramidal involvement.
Keywords: Gaucher’s disease, gait analysis, joint excursion, extrapyramidal system, Parkinson disease, parkinsonism
DOI: 10.3233/JPD-150660
Journal: Journal of Parkinson's Disease, vol. 6, no. 1, pp. 191-195, 2016
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
[email protected]
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office [email protected]
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
如果您在出版方面需要帮助或有任何建, 件至: [email protected]