Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Hall, Julie M.a; b | Shine, James M.a; c; d | O’Callaghan, Clairea; c; e | Walton, Courtney C.a; f | Gilat, Morana | Naismith, Sharon L.f | Lewis, Simon J.G.a; *
Affiliations: [a] Parkinson’s Disease Research Clinic, Brain and Mind Centre, University of Sydney, NSW, Australia | [b] School of Social Sciences and Psychology, University of Western Sydney, Sydney, NSW, Australia | [c] Neuroscience Research Australia and School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia | [d] School of Psychology, Stanford University, California, USA | [e] Behavioural and Clinical Neuroscience Institute, University of Cambridge, UK | [f] Healthy Brain Ageing Program, Ageing Brain Centre, Brain and Mind Centre, University of Sydney, NSW, Australia
Correspondence: [*] Correspondence to: A/Prof. Simon Lewis, Level 2, 100 Church St, Camperdown, 2050 NSW, Australia. Tel.: +61 2 9351 0702; Fax: +61 2 9351 0855; E-mail: [email protected]
Abstract: Background:Freezing of gait is a common disabling symptom of Parkinson’s disease (PD) with limited treatment options. The pathophysiological mechanisms of freezing behaviour are still contentious. Objective:To investigate the prevalence of freezing of gait and its associations with increasing disease severity to gain a better understanding of the underlying pathophysiology. Methods:This exploratory study included 389 idiopathic PD patients, divided into four groups; early and advanced PD with freezing of gait, and early and advanced PD without freezing of gait. Motor, cognitive and affective symptoms, REM sleep behaviour disorder and autonomic function were assessed. Results:Regardless of disease stage, patients with freezing of gait had more severe motor symptoms and a predominant non-tremor phenotype. In the early stages, freezers had a selective impairment in executive function and had more marked REM sleep behaviour disorder. Autonomic disturbances were not associated with freezing of gait across early or advanced disease stages. Conclusion:These findings support the notion that impairments across the frontostriatal pathways are intricately linked to the pathophysiology underlying freezing of gait across all stages of PD. Features of REM sleep behaviour disorder suggest a contribution to freezing from brainstem pathology but this does not extend to more general autonomic dysfunction.
Keywords: Parkinson’s disease, freezing of gait, disease stage, pathophysiology, executive function
DOI: 10.3233/JPD-150581
Journal: Journal of Parkinson's Disease, vol. 5, no. 4, pp. 881-891, 2015
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
[email protected]
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office [email protected]
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
如果您在出版方面需要帮助或有任何建, 件至: [email protected]