Affiliations: Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Korea | Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Korea
Note:  Correspondence to: Beom S. Jeon, MD, PhD, Department of Neurology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Korea. Tel.: +82 2 2072 2876; Fax: +82 2 3672 7553; E-mail: [email protected]
Abstract: The human impulsivity-related trait has a complex background that is influenced by genetic and non-genetic factors. Impulsivity-related genetic factors have been evaluated in the field of psychiatry previously. Many previous reports have suggested that genetic variants associated with the hyperstimulation of the dopaminergic and serotonergic systems may have main roles in impulsivity. Although impulse control and related behaviors (ICRBs) in Parkinson's disease (PD) are now recognized as important nonmotor symptoms, ICRBs has seldom been evaluated for its genetic susceptibility in PD. This review will address genetic studies on ICRBs in the general population and PD. Although this trait has genetic susceptibility in part, it should be remembered that human trait is not entirely determined by genes.
Keywords: Genetics, polymorphism, impulse control disorders, Parkinson's disease