Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Gudala, Kapil | Bansal, Dipika | Muthyala, Harini
Affiliations: Department of Pharmacy Practice, National Institute of Pharmaceutical Education and Research, Mohali, Punjab, India
Note: [] Correspondence to: Dr. Dipika Bansal, Department of Pharmacy Practice, Research block, National Institute of Pharmaceutical Education and Research, Mohali, Punjab-160062, India. E-mails: [email protected]; [email protected] (K. Gudala); [email protected] (H. Muthyala).
Abstract: Background: Results from several epidemiological studies found a potential role of cholesterol metabolism in Parkinson's disease (PD) pathogenesis. Further several studies assessed relation between dietary intake of cholesterol and risk of PD, although these studies showed varied results but give a clue of association between serum cholesterol and PD. Objective: We therefore examined the association between serum cholesterol and risk of PD. Methods: PubMed database and bibliographies of retrieved articles were searched for observational studies (published up to January 2013) investigating the relationship between serum cholesterol and PD. Pooled risk ratio (RR) was calculated using random-effects model. Subgroup, sensitivity analysis and publication bias were also done. Results: Eight relevant studies were identified, consisting of 4 each case-control and cohort studies involving a total of 246,112 subjects including 5,488 PD cases. Because of significant heterogeneity (pheterogeneity < 0.001, I2 = 70.34%) was observed, a random-effects model was chosen over a fixed-effects model. A combined analysis of 8 studies found no significant association between serum cholesterol and risk of PD (RR 0.87, 95% CI 0.67–1.13; p = 0.41). Conclusions: We observed no probable association between serum cholesterol and risk of PD.
Keywords: Meta-analysis, Parkinson's disease, serum cholesterol
DOI: 10.3233/JPD-130196
Journal: Journal of Parkinson's Disease, vol. 3, no. 3, pp. 363-370, 2013
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
[email protected]
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office [email protected]
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
如果您在出版方面需要帮助或有任何建, 件至: [email protected]