Affiliations: Division of Movement Disorders, Great Lakes NeuroTechnologies Inc., Cleveland, Ohio, USA | Department of Neurology, University of Rochester Medical Center, Rochester, New York, USA
Note:  Correspondence to: Thomas Mera, MS, Great Lakes NeuroTechnologies Inc. 10055 Sweet Valley Drive, Cleveland, Ohio 44125, USA. Tel.: +1 216 361 5410; Fax: +1 216 361 5420; E-mail: [email protected]
Abstract: Background: Chronic use of medication for treating Parkinson's disease (PD) can give rise to peak-dose dyskinesia. Adjustments in medication often sacrifice control of motor symptoms, and thus balancing this trade-off poses a significant challenge for disease management. Objective: To determine whether a wrist-worn motion sensor unit could be used to ascertain global dyskinesia severity over a levodopa dose cycle and to develop a severity scoring algorithm highly correlated with clinician ratings. Methods: Fifteen individuals with PD were instrumented with a wrist-worn motion sensor unit, and data were collected with arms in resting and extended positions once every hour for three hours after taking a levodopa dose. Two neurologists blinded to treatment status viewed subject videos and rated global and upper extremity dyskinesia severity based on the modified Abnormal Involuntary Movement Scale (mAIMS). Linear regression models were developed using kinematic features extracted from motion sensor data and extremity, global, or combined (average of extremity and global) mAIMS scores. Results: Dyskinesia occurring during a levodopa dose cycle was successfully measured using a wrist-worn sensor. The logarithm of the power spectrum area between 0.3–3 Hz and the combined clinician scores resulted in the best model performance, with a correlation coefficient between clinician and model scores of 0.81 and root mean square error of 0.55, both averaged across the arms resting and extended postures. Conclusions: One sensor unit worn on either hand can effectively predict global dyskinesia severity during the arms resting or extended positions.