Affiliations: Department of Neurosciences, Monash Medical Centre, Clayton, VIC, Australia | Flinders Medical Centre, Adelaide, SA, Australia
Note:  Correspondence to: Dominic Thyagarajan, MD, FRACP, Professor of Neuroscience and Director of Neurology; Laura Perju-Dumbrava, MD, Department of Neuroscience, Level 5, Block E, Monash Medical Centre, 246, Clayton Road, Clayton VIC 3168, Australia. Tel.: +61 395945527; Fax: +61 395945662; E-mail: [email protected]
Abstract: Although effective deep brain stimulation of the subthalamic nucleus (STN-DBS) is reported in G2019S leucine-rich repeat kinase 2 (LRRK2) parkinsonism, response to surgery in other LRRK2 mutations has not been previously reported. We present an affected individual from the Lincolnshire pedigree (Y1699C), on whom bilateral STN-DBS was performed to control severe motor fluctuations and dyskinesias. He showed a marked improvement in Unified Parkinson's Disease Rating Scale (UPDRS) Part III scores in the “on” and “off” states, sustained for more than three years. Bilateral STN-DBS in LRRK2-parkinsonism with the Y1699C mutation can be as effective as in sporadic PD.