You are viewing a javascript disabled version of the site. Please enable Javascript for this site to function properly.
Go to headerGo to navigationGo to searchGo to contentsGo to footer
In content section. Select this link to jump to navigation

Impact of SARS-CoV-2 Infection Among Non-Invasive Ventilated ALS Patients



The impact of SARS-CoV-2 infection among neuromuscular diseases with respiratory involvement, including amyotrophic lateral sclerosis (ALS), is still to be elucidated.


We aim to characterize the clinical outcome of ALS patients non-invasive ventilated (NIV), following SARS-CoV-2 infection.


We analyzed retrospectively our patients followed regularly at our ALS clinic, from the beginning of the COVID-19 pandemic (middle March 2020) to March 2021. We included patients on NIV with a documented SARS-CoV-2 infection. We recorded demographic and clinical data, including from the acute infectious illness.


Three men with spinal-onset ALS are described, mean age of onset was 55±9.1 years (45–61), and mean disease duration was 17.5±15.9 months (6.1–41). All of them were wheelchair-bounded, with a mean ALSFRS-R of 15.3±0.6 (15–16). One patient used NIV 15 hours/day, 2 between 4 to 7 hours/day, and all used assisted coughing twice daily. None had coexistent comorbidities. They were managed for SARS-CoV-2 infection as outpatients with fluticasone, bronchodilators, azithromycin and increasing frequency of assisted coughing. Supplemental oxygen (mean of 2 liters per minute) was needed in two patients, and one required NIV also during the daytime. Total recovery from SARS-CoV-2 infection was observed in all, despite being in an advanced stage of their disease, with severe respiratory involvement.


Prompt medical treatment is recommended for ALS patients with severe disease infected by SARS-CoV-2.


The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first identified in December 2019 in the city of Wuhan (China) [1]. SARS-CoV-2 infection has caused an outbreak of the underlying disease, Coronavirus-Disease-19 (COVID-19), which has continued to spread rapidly throughout China and then worldwide. The most common symptoms of COVID-19 are fever, cough, and fatigue; however, in more severe cases, patients may develop pneumonia, acute respiratory distress syndrome and even multiorgan failure, eventually leading to death [2].

It has been reported that concomitant chronic diseases are strongly associated with COVID-19 severity, in particular arterial hypertension, diabetes, cardiovascular, respiratory and chronic kidney disease [3, 4]. In addition, obesity has also been found as a predictor for poor prognosis [5, 6]. However, little is known about the impact of SARS-CoV-2 infection among neuromuscular diseases, including amyotrophic lateral sclerosis (ALS). We aim to characterize the clinical outcome of ALS patients with severe respiratory compromise following SARS-CoV-2 infection.


We analyzed retrospectively ALS patients followed regularly at our ALS clinic, from the beginning of the COVID-19 pandemic (middle March 2020) to 31st March 2021. We included patients with ALS, as defined by the new Gold Coast criteria [7]. We included patients on non-invasive ventilation (NIV, overnight or longer) with a positive nasopharyngeal exudate for SARS-CoV-2 determined by reverse-transcription polymerase chain reaction. We recorded clinical data, including gender, onset age, onset region, disease duration, functional status (ALSFRS-R), number of hours on NIV and comorbidities. COVID-19 symptoms, management and support treatment were also recorded.

All procedures were performed in accordance with ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.


Three sporadic ALS patients (1.5%) were included from a total of 204. All of them were men with spinal-onset, the mean age of onset was 55±9.1 years (range, 45–61) and the mean disease duration was 17.5±15.9 months (range, 6.1–41). The mean ALSFRS-R score was 15.3±0.6 (range, 15–16) and all of them were wheelchair-bounded. Patient 2 was dependent on NIV for at least 15 hours daily and patient 3 did not tolerate well nocturnal NIV (maximum usage of 4 hours) –Table 1. All used assisted coughing with a mean of twice daily. None had particular comorbidities, including arterial hypertension, diabetes, cardiovascular, lung or chronic kidney disease. One patient was living in skilled nursing facilities, while the remaining were in their own homes.

Table 1

Nocturnal oximetry results and non-invasive ventilation usage before, during and 30 days after SARS-CoV2 infection

BaselineAcute phase30 days after
Nocturnal oximetryNIV usage *Nocturnal oximetryNIV usageNocturnal oximetryNIV usage
Patient 194%7 h89%14 h94%14 h
Patient 293%15 h89%20 h92%16 h
Patient 393%4 h92%2 h93%7 h

 *Non-invasive ventilation average usage.

SARS-CoV-2 transmission occurred through facility outbreak or a familial positive contact. Fever, cough, and increase respiratory fatigue with percutaneous oxygen desaturation (89–92%) were the main COVID-19 symptoms. Only one patient stayed in the urgency yard for two days following SARS-CoV-2 infection, but all of them were managed as outpatients. Supplemental oxygen was needed in two patients (2 liters per minute). An additional one required NIV also during the daytime. It is noteworthy to mention that patient 3 needed ventilation parameters adjustment, in particular increased expiratory positive airway pressure, which have compromised even more its compliance to NIV during the acute phase. Increased frequency of assisted cough device usage was required. Two inhaled fluticasone 250μg 2id was added to the previous used bronchodilators (salbutamol and ipratropium) plus prophylactic azithromycin per os 500 mg daily for up to three days. Nocturnal oximetry and NIV usage before, during and 30 days after SARS-CoV2 infection and treatment support through the acute phase are summarized in Tables 1 and 2, respectively.

Table 2

Treatment management during SARS-CoV2 infection

MucolyticsBronchodilators + Fluticasone *Cough-assist *2Prophylactic azithromycin *3Ventilation parameters adjustmentOxygen support
Patient 1XXXX2 L/min for up 20 days
Patient 2XXX2 L/min up to 15 days
Patient 3XXXX

 *3Bronchodilators (four inhaled salbutamol plus ipratropium)+two inhaled fluticasone 250μg 2id;  *2Increase usage;  *3500 mg/daily for up three days.

This study has some limitations, in particular the low number of infected ALS patients. In addition, there is no information regarding pulmonary imaging data during the acute phase of SARS-CoV2-2 infection, because thoracic scans were not performed. On the other hand, as the ALS patients were managed as outpatients, we have not enough data to calculate SARS-CoV-2 severity score. In Portugal, infected outpatients are not routinely submitted to SARS-CoV-2 test to declare cure, so we do not know the actual number of days of positivity.

All patients recovered from the SARS-CoV-2 infection without additional complications, returning to their baseline condition, after a mean time of one month. In fact, patient 1 could have reduced NIV usage following SARS-Cov2 infection if he would accept changing a nasal to a facial mask. On the other hand, patient 3 have its NIV parameters adjustment to the baseline level, and now have a better compliance.


Reviewing the literature few reports of patients with neuromuscular disorders and affected by COVID-19 have been published. The outcome of patients with myasthenia gravis was positive [8]. It is reasonable to anticipate that patients with poor respiratory function have an increased risk of severe complications when infected by SARS-CoV-2. However, one recent study concluded that patients with chronic obstructive pulmonary disease and emphysema hospitalized with COVID-19 may not have worse outcomes [9].

To our best knowledge, this is the first report describing the clinical outcome ALS patients with severe respiratory impairment, and with symptoms related to SARS-CoV-2 infection. In this small cohort, it is noteworthy that all patients have survived COVID-19 despite being in an advanced stage of the disease, depended on NIV. On the other hand, comorbidities commonly associated with COVID-19 severity were absent in our patients. Our findings support that prompt medical care is recommended in patients with severe ALS disease and SARS-CoV-2 infection and indicates that the outcome can be favorable in spite of the severe respiratory insufficiency.


None of the authors have potential conflicts of interest to be disclose.


This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.



Hui DS , E IA , Madani TA , Ntoumi F , Kock R , Dar O , et al. The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health –The latest 2019 novel coronavirus outbreak in Wuhan, China. Int J Infect Dis. 2020;91:264–6.


Rothan HA , Byrareddy SN . The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. J Autoimmun. 2020;109:102433.


Wang X , Fang X , Cai Z , Wu X , Gao X , Min J , et al. Comorbid Chronic Diseases and Acute Organ Injuries Are Strongly Correlated with Disease Severity and Mortality among COVID-19 Patients: A Systemic Review and Meta-Analysis. Research (Wash D C). 2020;2020:2402961.


Yang J , Zheng Y , Gou X , Pu K , Chen Z , Guo Q , et al. Prevalence of comorbidities and its effects in patients infected with SARS-CoV- a systematic review and meta-analysis. Int J Infect Dis. 2020;94:91–5.


Takagi H . Risk and protective factors of SARS-CoV-2 infection. J Med Virol. 2021;93:649–51.


Zhang X , Lewis AM , Moley JR , Brestoff JR . A systematic review and meta-analysis of obesity and COVID-19 outcomes. Sci Rep. 2021;11:7193.


Shefner JM , Al-Chalabi A , Baker MR , Cui LY , de Carvalho M , Eisen A , et al. A proposal for new diagnostic criteria for ALS. Clin Neurophysiol. 2020;131(8):1975–8.


Rein N , Haham N , Orenbuch-Harroch E , Romain M , Argov Z , Vaknin-Dembinsky A , et al. Description of 3 patients with myastheniagravis and COVID-19. J Neurol Sci. 2020;417:117053.


Marron RM , Zheng M , Romero GF , Zhao H , Patel R , Leopold I , Thomas A , Standiford T , Kumaran M , Stewart NP , Criner GJ . Impact of Chronic Obstructive Pulmonary Disease and Emphysema on Outcomes of Hospitalized Patients with COVID-19 Pneumonia. Chronic Obstr Pulm Dis 2021 DOI: 10.15326/jcopdf.2020.0200.