Affiliations: [a] Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
| [b] Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA
| [c] Biogen, Cambridge, MA, USA
Correspondence to: Pamela M. Rist, ScD, Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital, 900 Commonwealth Avenue, 3rd floor, Boston, MA 02215, USA. Tel.: +1 617 278 0835; Fax: +1 617 731 3843 E-mail: [email protected].
Abstract: Little is known about the feasibility of using long-term stored blood samples to measure neurofilament levels and about long-term changes in neurofilament levels among healthy individuals. We performed a pilot study among 26 adult men in preparation for a larger-scale study of the natural history of neurofilament levels. Median change over 14 years in pNf-H was 97.1 pg/mL (IQR: 5.0 to 242.0 pg/mL) and in Nf-L was 2.117 pg/mL (IQR: –2.691 to 3.393 pg/mL). We demonstrated the feasibility of measuring neurofilament concentrations in stored blood samples and found a trend between age and increases in Nf-L levels among adults.