Affiliations: [a] Instituto de Fisiologia, Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal
Departments of Neurology and Neuroscience, Barts and the London School of Medicine, Queen Mary University of London, United Kingdom
Department of Neurology, Centro Hospitalar de Lisboa Central, Lisbon, Portugal
Correspondence to: Professor M. de Carvalho Institute of Phy-siology Faculty of Medicine- University of Lisbon Av. Professor Egas Moniz Lisbon 1649-028, Portugal E-mail: [email protected].
Note:  These authors have contributed equally to this study.
Abstract: In amyotrophic lateral sclerosis (ALS) lower plasma creatinine level has been associated with shorter survival and faster functional decline. It has not been clear if creatinine is associated with respiratory outcome. We analyzed retrospectively a population of unselected ALS patients. Multiple-regression and Cox-regression analyses were performed. We included 233 patients, mean age 62.8, mean disease duration of 18.6 months. At baseline, creatinine was significantly associated with ALSFRS-R, but not with its decline rate. No predictive value was disclosed for FVC, its decline rate, or with survival. We did not confirm that creatinine is a marker of respiratory outcome.