Hospital General Universitario Gregorio Marañón, Universidad Complutense de Madrid, Madrid, Spain
Nephrology Service, Hospital General Universitario Gregorio Marañón, Madrid, Spain
| [c] Pediatric Rehabilitation Service, Hospital General Universitario Gregorio Marañón, Madrid, Spain
| [d] Neonatology Service, Hospital General Universitario Gregorio Marañón, Madrid, Spain
Address for correspondence: C. Nicolás, Hospital General Universitario Gregorio Marañón, Universidad Complutense de Madrid, Doctor Esquerdo 46. 28007 Madrid, Spain. Tel.: +34 665056502; E-mail: firstname.lastname@example.org.
Abstract: BACKGROUND:Preeclampsia affects up to 10% of pregnancies worldwide and is one of the main causes of fetal morbidity and mortality. Although it has been linked to developmental delay, its long-term effects on neurologic development in children have yet to be sufficiently quantified. OBJECTIVES:To evaluate whether preeclampsia’s severity and its obstetric management correlate to the degree of disability in these infants. MATERIALS AND METHOD:This is an observational and descriptive study performed on a population of 96 women who were diagnosed with preeclampsia at Hospital General Universitario Gregorio Marañón between 2007 and 2014, and their 111 children. To evaluate the mother, we gathered data pertaining to her medical history, renal function markers, and medical management of the preeclampsia. To assess the children, we collected fetal growth measurements, acute fetal distress markers and main diagnoses at birth. We used the Pediatric Evaluation of Disability Inventory in its computerized adaptive test version (PEDI-CAT) to study performance in the relevant areas, and the TNO-AZL Preschool children Quality of Life (TAPQOL) to estimate health-related quality of life. RESULTS:PEDI-CAT percentiles were consistently lower in the social/cognitive domain than in other areas. Lower social/cognitive percentiles were associated to both lower maternal IgG levels and presence of necrotizing enterocolitis during the neonatal period. CONCLUSIONS:A connection between preeclampsia and poor social/cognitive outcomes exists that warrants further research.
Keywords: Quality of life, cognitive delay, social functioning, autism spectrum disorders, immunoglobulin G, necrotizing enterocolitis, gut microbiome, PEDI-CAT, TAPQOL