Department of Maternal-Fetal Medicine, University of Connecticut School of Medicine, Farmington, CT, USA
Department of Neonatology, Connecticut Children’s Medical Center, Hartford, CT, USA
Department of Pathology, University of Connecticut School of Medicine, Farmington, CT, USA
Address for correspondence: Kari M. Stirling, M.D., 13601 Bruce B. Downs Blvd, Tampa, FL 33613, USA. Tel.: +1 215 370 4188; E-mail: [email protected].
Abstract: OBJECTIVE: Genital mycoplasmas (GMs) can be associated with chorioamnionitis and preterm birth, but are viewed as commensal organisms with low virulence. We sought to determine if cervical GM colonization is associated with histologic chorioamnionitis independent of infection with other bacteria. STUDY DESIGN: Retrospective study of patients who delivered preterm, had cervical cultures for GMs, and placental cultures for bacteria other than GM. GM positive patients were compared to GM negative patients. Histologic grading of placentas was compared between GM negative patients with negative placental cultures (Group 1), GM positive patients with negative placental cultures (Group 2), GM negative patients with positive placental cultures (Group 3) and GM positive patients with positive placental cultures (Group 4). RESULTS: GM positive patients were less likely than GM negative patients to have placental cultures positive for other bacteria (39% versus 47%, P = 0.0071). Group 2 had higher rates of membrane inflammation compared to Group 1 (p = 0.0079), and no significant difference in rates of membrane inflammation compared to Groups 3 or 4 (p = 0.36, p = 0.18). GM positivity was independently associated with increased membrane inflammation and decreased inflammation in the chorionic plate. CONCLUSIONS: GM colonization is associated decreased inflammation of the chorionic plate, and increased inflammation of the membranes.