Loma Linda University Children’s Hospital, Loma Linda, CA, USA
Children’s Mercy Hospital, Kansas City, MO, USA
Corresponding author: Joanne E. Baerg MD, Associate Professor, Division of Pediatric Surgery, Loma Linda University Children’s Hospital, Rm. 21111, Coleman Pavilion, 11175 Campus St., Loma Linda, CA 92354, USA. Tel.: +909 558 4619; Fax: +909 558 7978; firstname.lastname@example.org
Abstract: OBJECTIVE:The objective of this study was to identify predictors of mortality in infants with omphalocele. METHODS:Medical records of infants with omphalocele born between January 1992 and June 2012, with follow-up toDecember 2012, were retrospectively reviewed. Survivors and non-survivors were compared. Evidence for pulmonary hypertension was sought between the second and seventh day after birth. All included infants had increased right ventricular pressures (RVP >40 mmhg) on echocardiogram on the second day of life with increased oxygen requirements, therefore, the finding of increased pressure was not considered a result of the transitional circulation. Logistic regression was used to evaluate the importance and independence of various factors. RESULTS:Of 51 infants whose records were reviewed, 13 died (25%) and 38 survived (75%). The median time to death was 34 days (range: 4 –408 days). The median follow-up time for those who died was 1.5 years (range: 0.01–15 years) and for survivors was 2.6 years (range: 0.08–15 years). Logistic regression revealed that respiratory insufficiency at birth (OR: 14.8; 95% CI: 2.5–85.0) and pulmonary hypertension (OR: 6.4; 95% CI: 1.1–39.0) were independently associated with mortality. CONCLUSION:Respiratory insufficiency after birth and pulmonary hypertension are independent predictors of mortality in infants with omphalocele.