Affiliations: Division of Pediatric Nephrology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA | The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA
Note:  Corresponding author: Dr. Nianzhou Xiao, Pediatric Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue – S215, Cincinnati, 45229 OH, USA. Tel.: +1 513 636 8647; E-mail: Nianzhou.Xiao@cchmc.org
Abstract: Neonatal systemic hypertension is an underappreciated etiology of cardiac failure. We present a series of three neonates who presented in cardiogenic shock secondary to severe hypertension, recognized after initial resuscitation efforts. Although the underlying etiology of the hypertension varied, all three patients had improved hemodynamics after their blood pressure was controlled. These cases suggest that neonates presenting in cardiogenic shock with hypertension, and without structural heart disease, may benefit from a thorough renal evaluation and institution of anti-hypertensive therapy.