Affiliations: Boekelheide Neonatal Intensive Care Unit, Sanford School of Medicine of the University of South Dakota, Sioux Falls, SD, USA | Methodology and Data Analysis Center, Sanford Research, Sanford Health System, Sioux Falls, SD, USA
Note:  Corresponding author: Dennis C. Stevens, Boekelheide Neonatal Intensive Care Unit, Sanford School of Medicine of the University of South Dakota, 1600 West 22nd Street, Sioux Falls, SD 57117 5039, USA. Tel.: +1 605 312 1050; Fax: +1 605 312 1008; E-mail: [email protected]
Abstract: Objectives: To compare a composite of severe adverse outcomes of care using the open-bay (OPBY) and single-family room (SFR) neonatal intensive care unit (NICU) designs. Study Design: Retrospective cohort analysis of a composite indicator of death, grade III-IV intraventricular hemorrhage, >28 days of supplemental oxygen or the need for retinal laser ablation surgery. Data for 3143 neonates over a five-year period were analyzed. Propensity score was calculated as the predicted probability of a neonate being admitted to the OPBY NICU. This indicated that the two cohorts were comprised of similar subjects. Equivalence testing was also used to compare the two study cohorts with logistic regression modeling the occurrence of the composite endpoint. Results: Logistic regression did not indicate a significant difference in composite adverse outcomes for the OPBY and SFR NICU. Equivalence testing and the use of the propensity scores confirmed the comparability of the two study cohorts. Conclusions: The large sample and the confirmation of equivalence of the two study cohorts provides great confidence that in this investigation there was no difference in composite of serious adverse outcomes of care using either the OPBY or SFR NICU design.
Keywords: Evidence-based NICU design, outcomes of care, NICU morbidity, single-family room NICU