Affiliations: [a]
McMaster University, Section of Neonatology, Pediatrics Department, Hamilton, ON, Canada
| [b]
University of Manitoba, Section of Neonatology, Pediatrics Department, Winnipeg, MB, Canada
| [c]
University of Manitoba, Section of Neonatology, Pediatrics Department, Winnipeg, MB, Canada
Correspondence:
[*]
Address for correspondence: Reem Amer, MD, McMaster University, Section of Neonatology, Pediatrics Department, Hamilton ON, L8S4K, Canada. E-mail: [email protected].
Abstract: OBJECTIVE:To validate the vasoactive inotropic score as a predictor of the severity of compromised systemic circulation and mortality in preterm infants. METHODS:A retrospective study was conducted on preterm infants with Compromised systemic circulation [hypotension±lactic acidosis±oliguria] who received a cardiovascular support, we calculated the vasoactive inotropic score (VIS) and cumulative exposure to cardiovascular medications over time (VISct). Receiver operator curve was constructed to predict the primary outcome which was death & refractory hypotension. RESULTS:VIS had an area under the curve of 0.73 (95% CI 0.85–0.98, p < 0.001). A VIS cut off of 25 has sensitivity and specificity of 66% and 92%, and positive and negative predictive values of 78.5% and 83%, respectively. CONCLUSION:High VIS predicts the severity of Compromised systemic circulation and mortality rate in preterm infants.
