Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Case Report
Authors: Margulies, Samantha L.a; * | Corrigan, K.b | Bathgate, S.c | Macri, C.c
Affiliations: [a] Department of Obstetrics and Gynecology, Yale Medicine, New Haven, CT, USA | [b] School of Medicine and Health Sciences, George Washington University, Washington, DC | [c] Department of Obstetrics and Gynecology, George Washington University, Washington, DC
Correspondence: [*] Address for correspondence: Samantha Margulies, MD, Department of Obstetrics and Gynecology, Yale Medicine, New Haven, CT 06520, USA. E-mail: [email protected].
Abstract: BACKGROUND:Addison’s disease is an uncommon condition encountered during pregnancy; however, pregnant patients with Addison’s disease are at higher risk for multiple pregnancy related complications. Treatment during pregnancy involves steroid replacement therapy. CASE REPORT:A 34-year-old previously healthy G2P1001 presented with lethargy, skin hyperpigmentation, polyuria, and salt craving. Laboratory evaluation showed hyperkalemia, hyponatremia, elevated ACTH, and low cortisol. The patient terminated the pregnancy due to her symptoms. She was then placed on a regimen of hydrocortisone and fludrocortisone, leading to symptom resolution. On second presentation as a G5P1031, her Addison’s disease was managed with hydrocortisone and fludrocortisone. When Addison’s symptoms recurred, ACTH levels were checked to determine if her current medications could be optimized. She ultimately delivered a healthy male infant vaginally. For her third presentation as a G6P2032, her pregnancy was managed in a similar manner to the previous pregnancy. CONCLUSION:There is currently minimal cohesive literature on the management of Addison’s disease during pregnancy. Patients can be managed successfully by monitoring for recurrence of Addison’s symptoms and adjusting medication dosing as needed.
Keywords: Addison’s disease, adrenal insufficiency, pregnancy, obstetrics
DOI: 10.3233/NPM-190231
Journal: Journal of Neonatal-Perinatal Medicine, vol. 13, no. 2, pp. 275-278, 2020
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
[email protected]
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office [email protected]
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
如果您在出版方面需要帮助或有任何建, 件至: [email protected]