Affiliations: Department of Pediatrics, University of Maryland Baltimore, School of Medicine, Baltimore, MD, USA
Address for correspondence: Suma Bhat Hoffman, M.D., Department of Pediatrics, University of Maryland, 110 S. Paca St, 8-S-153, Baltimore, MD 21201, USA. Tel.: +1 410 328 6003; Fax: +1 410 328 1076; E-mail: [email protected].
Abstract: OBJECTIVE:Determine how blood pressure differs in premature infants born small for gestational age (SGA). DESIGN:A retrospective study was conducted on inborn infants 24–32 weeks gestation. Mean arterial blood pressure (MAP) was collected and averaged every 12 h for the first 96 h of life. For each time point, the difference MAP in SGA vs. AGA infants was evaluated with t-testing. Linear mixed-effects modeling was performed to model MAP over time accounting for GA, BW, gender, and SGA status. RESULTS:356 subjects were evaluated. 52 (14.6%) were SGA. SGA infants were smaller, more likely male, exposed to maternal hypertension, born via caesarian section, and have chronic lung disease and retinopathy of prematurity. MAP in the SGA group more closely matched the MAP of AGA babies of similar GA for the first 24 h of life. Subsequently, SGA infants had lower MAPs more closely resembling their weight-matched counterparts. Mixed modeling showed GA to be significant, p < 0.0001 while BW though still marginally significant had less of an effect, p = 0.049. CONCLUSION:SGA infants have blood pressure that is strongly associated with GA in the first 24 hours of life, but then fails to increase at the same rate as their AGA counterparts.