Affiliations: [a] Department of Pediatric Surgery, Fujita Health University Hospital, Aichi, Japan
| [b] Department of Pediatric, Fujita Health University Hospital, Aichi, Japan
Address for correspondence: Shunsuke Watanabe, MD, Department of Pediatric Surgery, Fujita Health University Hospital, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi Prefecture 470-1192, Japan. Tel.: +81 562 93 9247 / +81 562 93 2323; Fax: +81 562 93 1951; E-mail: [email protected].
Abstract: PURPOSE:Recently, the number of births using assisted reproductive technologies (ART) has increased. An associated increase in the incidence of congenital malformations in babies conceived using this technology has also been reported. Therefore, we aimed to investigate the rate of malformations in babies with neonatal surgical diseases, who were conceived using ART. MATERIALS AND METHODS:Between January 2007 and December 2016, 1737 patients were admitted to our hospital. We analyzed the incidence of congenital cardiac diseases, genetic anomalies, and congenital anomalies of the kidney and urinary tract (CAKUT) in neonates conceived by ART. The χ2 test and logistic regression analysis were used to assess the odds ratios (ORs) for congenital malformations. A P-value < 0.05 indicated statistical significance. RESULTS:The OR for CAKUT was 16.94 for the first-birth neonates conceived using ART, [P < 0.05, AUC (area under the curve) = 0.86]. However, for non-surgery neonates, the OR for CAKUT was 5.99 (P = 0.15, AUC = 0.87), compared to 32.27 (P < 0.05, AUC = 0.93) for parallel conditions in surgery-neonates. CONCLUSION:Neonates conceived using ART are prone to develop CAKUT, which will need surgical treatment. Therefore, more management is necessary for associated malformations in these babies, particularly in cases with CAKUT.
Keywords: Neonate, advanced age primipara, assisted reproductive technology, associated malformation, congenital anomalies of the kidney and urinary tract (CAKUT)