Affiliations: [a] Department of Neonatology, Toho University Omori Hospital, Ota-ku, Tokyo, Japan
| [b] Department of Microbiology and Infectious Diseases, Toho University Faculty of Medicine, Ota-ku, Tokyo, Japan
| [c] Department of Pediatrics, Toho University Ohashi Hospital, Ohashi Meguro-ku, Tokyo, Japan
Address for correspondence: Yoko Shirai, M.D., 2-17-6, Ohashi, Meguro-ku, Tokyo, Japan. Tel.: +81 3 3468 1251; E-mail: firstname.lastname@example.org.
Abstract: INTRODUCTION:Methicillin-resistant Staphylococcus aureus (MRSA) is a common etiological agent of a life-threatening infection in neonatal intensive care units (NICUs). Neonates with very low birth weight and patients with serious diseases are more likely to be exposed to invasive procedures which make them at a high risk of MRSA colonization and infection. Since MRSA colonization is a risk factor for MRSA infection, prevention of MRSA transmission is an important issue in NICUs. NICUs in Japan practice standard contact precautions and active surveillance cultures (ASC) to prevent MRSA transmission. In this report, we analyzed the clinical characteristics of MRSA colonization and infection between January 2010 and December 2015 in our perinatal care center. METHODS:We conducted retrospective analysis of 1716 neonates hospitalized in our perinatal care center. RESULTS:120 cases had MRSA colonization (6.99%) and among them 33 neonates were infected. The duration of stay (P≤0.001) and the birth weight (P≤0.001) showed statistically significant differences between MRSA-colonized neonates and non-MRSA-colonized neonates. The number of central venous catheterization showed statistically significant differences (P = 0.001) and the number of digestive system diseases showed marginally significant differences (P = 0.072) between MRSA-colonized non-infected neonates and MRSA-infected neonates. CONCLUSIONS:As previous reports have shown, we present that the neonates with central venous catheterization were more likely to be infected with MRSA. We also need to pay attention to neonates with digestive system diseases, showing signs of infection, because they may be potentially infected with MRSA.