Department of Psychiatry, University of Iowa Hospital and Clinics, Iowa City, IA, USA
George Huntington Institute, Muenster, Germany
Department of Radiology, University of Muenster, Muenster, Germany
Department of Neurodegenerative Diseases and Hertie-Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
Correspondence to: Ellen van der Plas, PhD, W280 GH, 200 Hawkins Drive, Iowa City, IA 52242, USA. Tel.: +1 319 353 8544; E-mail: [email protected].
Abstract: Q-Motor is utilized across various clinical trials in adults with Huntington’s disease (HD) to provide quantitative, reliable assessments of motor abilities. With gene-knockdown therapies entering the clinic, development of preventative therapies for pediatric carriers of the HD mutation seems imminent. It is currently unclear if Q-Motor is useful for tracking changes in motor abilities in pediatric HD patients or at-risk youth, as most assessments have never been administered in children. We demonstrate the feasibility of administering Q-Motor tasks in a sample of children recruited from the community, and we show that Q-Motor is sensitive to age-related changes in motor abilities.