The development of the production technology of 177Lutetium trichloride

Article type: Research Article

Authors: Novikov, S.G.^a | Berintsev, A.V.^a | Alekseyev, A.S.^a | Svetukhin, V.V.^a | Kuznetsov, R.A.^a | Zhukov, A.V.^a | Fomin, A.N.^a | Kovalnogov, V.N.^{a; *} | Gorodetsky, V.G.^b | Karbolin, P.V.^b | Predeina, M.A.^b | Ivshin, S.A.^b | Ilyin, K.I.^b | Markov, D.V.^b

Affiliations: [a] S.P. Kapitsa Research Institute of Technology of Ulyanovsk State University, Ulyanovsk, Russia | [b] JSC “Institute of Reactor Materials”, Zarechny, Russia

Correspondence: [*] Corresponding author: V.N. Kovalnogov, S.P. Kapitsa Research Institute of Technology of Ulyanovsk State University, Ulyanovsk, Russia. E-mail: [email protected].

Abstract: The results of the development of a new technological process and equipment for the production of trichloride-lutetium-177 at the JSC “Institute of Reactor Materials” are presented. A new technological process is proposed for the production of a radiopharmaceutical precursor of lutetium trichloride 177LuCl3, which comprises more than thirty technological and control operations. New technological equipment has been developed to ensure the implementation of technological operations within the process. The behavior modeling of the devices being developed in high-intensity radiation fields has been carried out.

Keywords: Technology, lutetium-trichloride-177, reactor irradiation, technological equipment, automated system

DOI: 10.3233/JCM-180822

Journal: Journal of Computational Methods in Sciences and Engineering, vol. 18, no. 3, pp. 709-713, 2018