Affiliations: [a] Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Istanbul, Turkey | [b] Department of Natural Products Chemistry, Medical University of Lublin, Lublin, Poland
| [c] Department of Pharmacognosy with Medicinal Plant Garden, Medical University of Lublin, Lublin, Poland
| [d] Laboratory of Medicinal Plant Biotechnology, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, PR China
Corresponding author: Esra Capanoglu, Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak, Istanbul, Turkey. Tel.: +90 212 2857340; Fax: +90 212 2852925; E-mail: [email protected].
Abstract: Metabolomics, one of the most recent additions to the systems biology toolkit, has been used to study the metabolism and physiology of living organisms. In the field of food research, metabolomics has lately gained popularity as a technique for determining the quality, processing, and safety of raw materials and final food products, as well as for identifying biomarkers linked to food intake and disease. This review aimed to provide an overview of the current understanding of the analytical techniques used for metabolomics and their application to berries with a special emphasis on the in vivo studies. Specifically, identification of biomarkers of biological activity and in vivo metabolites of berries using metabolomics approach is covered.
Keywords: Metabolomics, LC-MS, polyphenols, gut microbiota