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Article type: Short Communication
Authors: Jann, Kaya; * | Cen, Stevenb | Santos, Mariellaa | Aksman, Leona | Wijesinghe, Dilminia | Zhang, Rua | Lynch, Kirstena | Ringman, John M.b | Wang, Danny J.a | for the Alzheimer’s Disease Neuroimaging Initiative1
Affiliations: [a] USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA | [b] Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Correspondence: [*] Correspondence to: Kay Jann, PhD, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, 2025 Zonal Avenue, Los Angeles, CA 90033, USA. Tel.: +1 323-44-BRAIN. E-mail: [email protected].
Note: [1] Data used in preparation of this article were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database (http://adni.loni.usc.edu). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report. A complete listing of ADNI investigators can be found at: http://adni.loni.usc.edu/wp-content/uploads/how_to_apply/ADNI_Acknowledgement_List.pdf.
Abstract: Reduced functional magnetic resonance imaging (fMRI)-complexity in Alzheimer’s disease (AD) progression has been demonstrated and found to be associated with tauopathy and cognition. However, association of fMRI-complexity with amyloid and influence of genetic risk (APOE ɛ4) remain unknown. Here we investigate the association between fMRI-complexity, tau-PET, and amyloid-PET as well as influence of APOE genotype using multivariate generalized linear models. We show that fMRI-complexity has a strong association with tau but not amyloid deposition and that the presence of an APOE ɛ4 allele enhances this effect. Thus fMRI-complexity provides a surrogate marker of impaired brain functionality in AD progression.
Keywords: Alzheimer’s disease, amyloid, APOE, fMRI-complexity, tau
DOI: 10.3233/JAD-240459
Journal: Journal of Alzheimer's Disease, vol. Pre-press, no. Pre-press, pp. 1-7, 2024
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