Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Nataraj, Athira | Kala, Annu | Pena, Stephanie Lissette Proskauer | Jezek, Karel | Blahna, Karel; *
Affiliations: Biomedical Center, Faculty of Medicine in Pilsen, Charles University, , Prague, Czech Republic
Correspondence: [*] Correspondence to: Karel Blahna, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, 30100, Czech Republic. Tel.: +420 377 593 804; E-mail: [email protected].
Abstract: Background:The hippocampal representation of space, formed by the collective activity of populations of place cells, is considered as a substrate of spatial memory. Alzheimer’s disease (AD), a widespread severe neurodegenerative condition of multifactorial origin, typically exhibits spatial memory deficits among its early clinical signs before more severe cognitive impacts develop. Objective:To investigate mechanisms of spatial memory impairment in a double transgenic rat model of AD. Methods:In this study, we utilized 9–12-month-old double-transgenic TgF344-AD rats and age-matched controls to analyze the spatial coding properties of CA1 place cells. We characterized the spatial memory representation, assessed cells’ spatial information content and direction-specific activity, and compared their population coding in familiar and novel conditions. Results:Our findings revealed that TgF344-AD animals exhibited lower precision in coding, as evidenced by reduced spatial information and larger receptive zones. This impairment was evident in maps representing novel environments. While controls instantly encoded directional context during their initial exposure to a novel environment, transgenics struggled to incorporate this information into the newly developed hippocampal spatial representation. This resulted in impairment in orthogonalization of stored activity patterns, an important feature directly related to episodic memory encoding capacity. Conclusions:Overall, the results shed light on the nature of impairment at both the single-cell and population levels in the transgenic AD model. In addition to the observed spatial coding inaccuracy, the findings reveal a significantly impaired ability to adaptively modify and refine newly stored hippocampal memory patterns.
Keywords: Alzheimer’s disease, place cell directionality, place field size, spatial memory, TgF344-AD rats
DOI: 10.3233/JAD-231386
Journal: Journal of Alzheimer's Disease, vol. 101, no. 1, pp. 259-276, 2024
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
[email protected]
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office [email protected]
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
如果您在出版方面需要帮助或有任何建, 件至: [email protected]