Self-Reported Sleep Duration and Bedtime Are Associated with Dementia Risk in Community-Dwelling People Aged 40–74 Years: The Murakami Cohort Study

Article type: Research Article

Authors: Bulycheva, Irina^a | Watanabe, Yumi^a | Kitamura, Kaori^a | Kabasawa, Keiko^b | Saito, Toshiko^a | Takahashi, Akemi^c | Kobayashi, Ryosaku^c | Oshiki, Rieko^c | Takachi, Ribeka^d | Tsugane, Shoichiro^e | Yamazaki, Osamu^f | Watanabe, Kei^g | Nakamura, Kazutoshi^{a; *}

Affiliations: [a] Division of Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan | [b] Department of Health Promotion Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan | [c] Department of Rehabilitation, Niigata University of Rehabilitation, Niigata, Japan | [d] Department of Food Science and Nutrition, Nara Women’s University Graduate School of Humanities and Sciences, Nara, Japan | [e] Graduate School of Public Health, International University of Health and Welfare, Tokyo, Japan | [f] Niigata Prefectural Government, Niigata, Japan | [g] Department of Orthopaedic Surgery, Niigata University Medical and Dental Hospital, Niigata, Japan

Correspondence: [*] Correspondence to: Kazutoshi Nakamura, Division of Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan. Tel.: +81 25 227 2124; E-mail [email protected].

Abstract: Background:Sleep is a potentially modifiable factor associated with dementia, including Alzheimer’s disease, but current evidence supporting this is insufficient. Objective:This study aimed to determine whether sleep duration and bedtime patterns are associated with the risk of dementia among middle-aged and older people. Methods:This cohort study had an eight-year follow-up period. Participants were 13,601 community-dwelling people aged 40–74 years living in Murakami (Niigata, Japan). Data were collected using a self-administered questionnaire. Predictors were self-reported sleep duration and bedtime, and the outcome was newly-diagnosed dementia determined using the long-term care insurance database. Covariates were demographic characteristics, body mass index, smoking, alcohol consumption, total physical activity, insomnia symptoms, disease history, and either bedtime or sleep duration. Cox proportional hazard models were used to calculate hazard ratios (HRs). Results:The mean age of participants at baseline was 59.2 years. Over a mean follow-up period of 8.0 years, 319 cases of dementia were observed. A long self-reported sleep duration relative to the reference sleep duration (7 hours) was associated with increased dementia risk, with the “8 hours” group (adjusted HR = 1.30, 95% CI:0.99–1.73) and “≥9 hours” group (adjusted HR = 1.46, 95% CI:1.00–2.15) having an increased risk (marginally significant) relative to the reference group. Early bedtime was associated with increased dementia risk (adjusted p for trend = 0.0010), with the “21 : 00 or earlier” group (adjusted HR = 1.61, 95% CI:1.14–2.28) having an increased risk relative to the reference (“23 : 00”). Conclusions:A long self-reported sleep duration and early bedtime are both associated with increased dementia risk in middle-aged and older people

Keywords: Alzheimer’s disease, bedtime, cohort study, dementia, sleep duration

DOI: 10.3233/JAD-231104

Journal: Journal of Alzheimer's Disease, vol. 99, no. 2, pp. 535-547, 2024