Affiliations: [a] Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA
| [b] Departments of Neurology and Epidemiology, University of California, San Francisco, CA, USA
| [c] San Francisco Veterans Affairs Health Care System, San Francisco, CA, USA
| [d] Department of Research Institute, California Pacific Medical Center, San Francisco, CA, USA
| [e] Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Correspondence:
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Correspondence to: Yue Leng, PhD, Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, 675 18th Street, San Francisco, CA 94107, USA. Tel.: +1 415 221 4810; E-mail: [email protected].
Abstract: Specific sleep characteristics have been associated with cognitive decline, Alzheimer’s disease, and related dementias; however, studies examining the association between multidimensional sleep (a more comprehensive integration of sleep parameters) and cognitive decline are lacking. Among 2,811 older men without dementia, those with none, 1-2, and 3–5 “poor” self-reported sleep health dimensions had an adjusted 10-year change score of global cognition (3MS) of 2.9, 4.0 and 3.5 points (p-trend = 0.05), and in executive function (Trails B) completion time of 36.7, 42.7, and 46.7 seconds (p-trend < 0.01), respectively. In conclusion, a multidimensional measure of sleep health was associated with greater cognitive decline.
Keywords: Alzheimer’s disease, cognitive decline, elderly, sleep health
