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Article type: Article Commentary
Authors: La Barbera, Liviaa; b | D’Amelio, Marcelloa; b; *
Affiliations: [a] Università Campus Bio-Medico di Roma, Rome, Italy | [b] IRCCS Santa Lucia Foundation, Rome, Italy
Correspondence: [*] Correspondence to: Marcello, D’Amelio, Università Campus Bio-Medico di Roma, Rome, Italy. E-mail: [email protected].
Abstract: In the last years, many clinical studies highlighted sex-specific differences in the pathophysiology of Alzheimer’s disease (AD). The recent paper published in the Journal of Alzheimer’s Disease shows the influence of sex on amyloid-β plaque deposition, behavior, and dopaminergic signaling in the 5xFAD mouse model of AD, with worse alterations in female mice. This commentary focuses on the importance of recognizing sex as a key variable to consider for a more precise clinical practice, with the challenge to develop sex-specific therapeutic interventions in neurodegenerative diseases such as AD.
Keywords: Alzheimer’s disease, amyloid-β , dopamine, 5xFAD
DOI: 10.3233/JAD-230681
Journal: Journal of Alzheimer's Disease, vol. 94, no. 4, pp. 1377-1380, 2023
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