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Article type: Short Communication
Authors: Lopes das Neves, Pedroa | Durães, Joãob; c; d; * | Silva-Spinola, Anuschkad | Lima, Marisab; d | Leitão, Maria Joãod | Tábuas-Pereira, Miguelb; c; d | Santana, Isabelb; c; d | Baldeiras, Inêsc; d
Affiliations: [a] Neurology Department, Hospital Professor Doutor Fernando Fonseca, Lisboa, Portugal | [b] Neurology Department, Centro Hospitalar Universitário de Coimbra, Coimbra, Portugal | [c] Faculty of Medicine, University of Coimbra, Coimbra, Portugal | [d] Centre for Innovative Biomedicine and Biotechnology (CIBB), Universidade de Coimbra, Coimbra, Portugal
Correspondence: [*] Correspondence to: João Durães, Centro Hospitalar e Universitário de Coimbra, Serviço de Neurologia, Praceta Professor Mota Pinto, 3004-561 Coimbra, Portugal. E-mail: [email protected].
Abstract: Serum light-chain neurofilaments (sNfL) have been investigated as a potential minimally invasive biomarker that could help in the diagnosis of patients with cognitive symptoms. We assessed the correlation between sNfL and cerebrospinal fluid (CSF) biomarkers (sNfL versus CSF NfL, ρ= 0.70, p < 0.001), the performance of sNfL in distinguishing controls from patients (controls versus frontotemporal dementia, area under curve 0.86), and sNfL differences in mild cognitive impairment according to amyloid-β (Aβ) deposition (Aβ versus non-Aβ, p = 0.017). Our results support the role of this biomarker in the screening and risk stratification of patients followed in a neurological consultation of a tertiary center.
Keywords: Alzheimer’s disease, biomarkers, frontotemporal dementia, mild cognitive impairment, neurofilament light chain
DOI: 10.3233/JAD-221208
Journal: Journal of Alzheimer's Disease, vol. 95, no. 2, pp. 391-397, 2023
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