Affiliations: [a]
Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL, USA
| [b]
Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA | [c]
Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA
| [d]
Department of Neurology, Rush University Medical Center, Chicago, IL, USA
Correspondence:
[*]
Correspondence to: Klodian Dhana MD, PhD, Rush University Medical Center, 1700 W Van Buren, Suite 245, Chicago, IL 60612, USA. Tel.: +1 312 942 3237; E-mail: [email protected].
Abstract: Background:Patients with stroke are at a higher risk of cognitive impairment and Alzheimer’s disease dementia. Objective:To quantify the role of lifestyle pre-stroke, post-stroke, and changes in lifestyle before and after stroke with cognitive decline in community-dwelling stroke survivors. Methods:Utilizing data from the Chicago Health and Aging Project, a population-based cohort study, we studied 1,078 individuals with stroke (662 incident and 416 prevalent) who underwent cognitive testing during the study period. A healthy lifestyle score was defined by scoring four behaviors: non-smoking, exercising, being cognitively active, and having a high-quality diet. The global cognitive score was derived from a comprehensive battery of 4 standardized tests. Results:The mean age at incident stroke was 78.2 years, and 60.1% were women. A healthy lifestyle pre-incident stroke was associated with a slower rate of cognitive decline after stroke. Participants with 3–4 healthy lifestyle factors pre-incident stroke had a slower cognitive decline after stroke by 0.046 units/year (95% CI 0.010, 0.083), or 47.7% slower, than participants with 0–1 healthy lifestyle factor. Lifestyle score post-prevalent stroke was not associated with cognitive decline. Changes in lifestyle behaviors from pre- to post-incident stroke were related to cognitive decline after stroke. Individuals who deteriorated their lifestyle quality after stroke had a faster cognitive decline by 0.051 units/year (β –0.051, 95% CI –0.090, –0.012) than participants with no change in lifestyle score. Conclusion:A healthy lifestyle pre-stroke was associated with a slower rate of cognitive decline in stroke survivors, highlighting the importance of primary prevention. After the stroke, changes in lifestyle behaviors may influence the cognitive abilities of older adults as they age.
