Peripheral Inflammatory Biomarkers of Alzheimer’s Disease

Article type: Review Article

Authors: Hao, Jing | Guo, Yanping^{; *} | Guo, Keke | Yang, Qingcheng

Affiliations: Department of Neurology, Anyang People’s Hospital, Xinxiang Medical University, Anyang, P.R. China

Correspondence: [*] Correspondence to: Yanping Guo, Department of Neurology, Anyang People’s Hospital, Xinxiang Medical University, Anyang 455000, P.R. China. Tel.: +86 372 2077817; E-mail: [email protected].

Abstract: Alzheimer’s disease (AD) is a neurodegenerative disease of unknown pathological origin. The clinical diagnosis of AD is time-consuming and needs to a combination of clinical evaluation, psychological testing, and imaging assessments. Biomarkers may be good indicators for the clinical diagnosis of AD; hence, it is important to identify suitable biomarkers for the diagnosis and treatment of AD. Peripheral inflammatory biomarkers have been the focus of research in recent years. This review summarizes the role of inflammatory biomarkers in the disease course of AD.

Keywords: Alzheimer’s disease, biomarkers, inflammatory, neurodegeneration

DOI: 10.3233/JAD-215422

Journal: Journal of Alzheimer's Disease, vol. 88, no. 2, pp. 389-398, 2022