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Article type: Research Article
Authors: Dou, Yuchaoa; 1 | Liu, Shuaia; 1 | Li, Yuqinga | Wu, Haoa | Chen, Huib; * | Ji, Yonga; c; *
Affiliations: [a] Tianjin Key Laboratory of Cerebrovascular and of Neurodegenerative Diseases, Tianjin Dementia Institute, Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China | [b] School of Nursing, Tianjin Medical University, Tianjin, China | [c] Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing, China
Correspondence: [*] Corresponding authors: Yong Ji, MD, PhD, Department of Neurology, Tianjin Huanhu Hospital, 6 Jizhao Road, Jinnan District, Tianjin 300350, China; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China. Tel.: +86 13612048681; E-mail: [email protected] and Hui Chen, Ph.D. School of Nursing, Tianjin Medical University, Tianjin 300070, China. E-mail: [email protected].
Note: [1] These authors contributed equally to this work.
Abstract: Background: The relationship between cholesterol level and the risk of developing Alzheimer’s disease has been well established, but the relationship between cholesterol level and Lewy body dementia (LBD) is still not well known. Objective: The aim of this case-control study was to explore the association between blood cholesterol levels and LBD in Chinese older adults. Methods: A total of 65 patients with LBD and 110 older adult controls were enrolled during the study period. The levels of triglyceride, total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and fasting glucose were measured separately. The associations between LBD, blood cholesterol levels, and fasting glucose levels were assessed using multiple binary logistic regression analyses adjusted for multiple covariates. Results: Increased plasma LDL-C levels and lower HDL-C levels were independently associated with the risk of LBD in models adjusted for age, sex, education, alcohol use status, smoking status, and vascular disorders. Higher fasting glucose levels may be associated with the risk of LBD. Conclusion: The results of this study suggest that elevated levels of LDL-C and reduced levels of HDL-C were associated with LBD development and therefore are potential nutritional risk factors for LBD. Adjusting diet and individualized and effective cholesterol-lowering therapy in high-risk adults may aid in the prevention or management of LBD.
Keywords: Cholesterol, fasting glucose, high-density lipoprotein cholesterol, Lewy body dementia, low-density lipoprotein cholesterol
DOI: 10.3233/JAD-215295
Journal: Journal of Alzheimer's Disease, vol. 86, no. 2, pp. 779-786, 2022
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