Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Jeong, Hee-Jeonga; b | Lee, Young-Mina; b; * | Park, Je-Mina; b | Lee, Byung-Daea; b | Moon, Eunsooa; b | Suh, Hwagyua; b | Kim, Hak-Jinc | Pak, Kyoungjuned | Choi, Kyung-Unb; e | Chung, Young-Inf
Affiliations: [a] Department of Psychiatry, Pusan National University School of Medicine, Busan, Republic of Korea | [b] Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea | [c] Department of Radiology, Pusan National University School of Medicine, Busan, Republic of Korea | [d] Department of Nuclear Medicine, Pusan National University School of Medicine, Busan, Republic of Korea | [e] Department of Pathology, Pusan National University School of Medicine, Busan, Republic of Korea | [f] Department of Psychiatry, Pusan National University School of Medicine, Yangsan, Republic of Korea
Correspondence: [*] Correspondence to: Dr. Young-Min Lee, MD, PhD, Department of Psychiatry, School of Medicine, Pusan National University, 305 Gudeok-Ro, Seo-Gu, Busan 602-739, Republic of Korea. Tel.: +82 51 240 7301; Fax: +82 51 248 3648; E-mail: [email protected].
Abstract: Background:A long-term follow-up study in patients with amnestic mild cognitive impairment (aMCI) is needed to elucidate the association between regional brain volume and psychopathological mechanisms of Alzheimer’s disease with psychosis (AD + P). Objective:The purpose of this study was to investigate the effect of the thickness of the angular cingulate cortex (ACC) on the risk of AD + P conversion in patients with aMCI. Methods:This was a hospital-based prospective longitudinal study including 174 patients with aMCI. The main outcome measure was time-to-progression from aMCI to AD + P. Subregions of the ACC (rostral ACC, rACC; caudal ACC, cACC) and hippocampus (HC) were measured as regions of interest with magnetic resonance imaging and the Freesurfer analysis at baseline. Survival analysis with time to incident AD + P as an event variable was calculated with Cox proportional hazards models using the subregions of the ACC and HC as a continuous variable. Results:Cox proportional hazard analyses showed that the risk of AD + P was associated with sub-regional ACC thickness but not HC volume: reduced cortical thickness of the left cACC (HR [95%CI], 0.224 [0.087–0.575], p = 0.002), right cACC (HR [95%CI], 0.318 [0.132–0.768], p = 0.011). This association of the cACC with the risk of AD also remained significant when adjusted for HC volume. Conclusion:We found that reduced cortical thickness of the cACC is a predictor of aMCI conversion to AD + P, independent of HC, suggesting that the ACC plays a vital role in the underlying pathogenesis of AD + P.
Keywords: Alzheimer’s disease, amnestic mild cognitive impairment, anterior cingulate cortex, incident psychosis
DOI: 10.3233/JAD-215005
Journal: Journal of Alzheimer's Disease, vol. 84, no. 4, pp. 1709-1717, 2021
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
[email protected]
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office [email protected]
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
如果您在出版方面需要帮助或有任何建, 件至: [email protected]