Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Peira, Enricoa; b; * | Grazzini, Matteob | Bauckneht, Matteoc; d | Sensi, Francescoa | Bosco, Paoloe | Arnaldi, Dariob; f | Morbelli, Silviac; d | Chincarini, Andreaa | Pardini, Matteob; f | Nobili, Flaviob; f
Affiliations: [a] INFN, Genoa, Italy | [b] Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Child and Maternal Health (DINOGMI), University of Genoa, Genoa, Italy | [c] IRCCS Ospedale Policlinico San Martino, Genoa, Italy | [d] Nuclear Medicine Unit, Dept. of Health Sciences (DISSAL), University of Genoa, Genoa, Italy | [e] IRCCS Stella Maris Foundation, Pisa, Italy | [f] Neurology Clinic, IRCCS Ospedale Policlinico San Martino, Genoa, Italy
Correspondence: [*] Correspondence to: Enrico Peira, Via Dodecaneso 33, I-16146, Genova, Italy. Tel.: +39 010 353 6496; E-mail: [email protected]. ORCID: 0000-0002-5834-8101.
Abstract: Background:In clinical practice, the amy-PET is globally inspected to provide a binary outcome, but the role of a regional assessment has not been fully investigated yet. Objective:To deepen the role of regional amyloid burden and its implication on clinical-neuropsychological features. Materials:Amy-PET and a complete neuropsychological assessment (Trail Making Test, Rey Auditory Verbal Learning Test, semantic verbal fluency, Symbol Digit, Stroop, visuoconstruction) were available in 109 patients with clinical suspicion of Alzheimer’s disease. By averaging the standardized uptake value ratio and ELBA, a regional quantification was calculated for each scan. Patients were grouped according to their overall amyloid load: correlation maps, based on regional quantification, were calculated and compared. A regression analysis between neuropsychological assessment and the regional amyloid-β (Aβ) load was carried out. Results:Significant differences were observed between the correlation maps of patients at increasing levels of Aβ and the overall dataset. The Aβ uptake of the subcortical gray matter resulted not related to other brain regions independently of the global Aβ level. A significant association of semantic verbal fluency was observed with ratios of cortical and subcortical distribution of Aβ which represent a coarse measure of differences in regional distribution of Aβ. Conclusion:Our observations confirmed the different susceptibility to Aβ accumulation among brain regions. The association between cognition and Aβ distribution deserves further investigations: it is possibly due to a direct local effect or it represents a proxy marker of a more aggressive disease subtype. Regional Aβ assessment represents an available resource on amy-PET scan with possibly clinical and prognostic implications.
Keywords: Amyloid PET, ELBA, regional amyloid, semi-quantification, standardized uptake value ratio
DOI: 10.3233/JAD-201156
Journal: Journal of Alzheimer's Disease, vol. 80, no. 1, pp. 383-396, 2021
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
[email protected]
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office [email protected]
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
如果您在出版方面需要帮助或有任何建, 件至: [email protected]